Antineoplastic agents, 326. The stereochemistry of bastadins 8, 10, and 12 from the bismarck archipelago marine sponge ianthella basta

George Pettit, Mark S. Butler, Charles G. Bass, Dennis L. Doubek, Michael D. Williams, Jean M. Schmidt, Robin Pettit, John N A Hooper, Larry P. Tackett, Melanie J. Filiatrault

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25 Scopus citations

Abstract

An investigation of cancer cell-growth inhibitory constituents of the Papua New Guinea marine sponge lanthella basta led to isolation of the C-6 hydroxybastadins 8 [1], 10 [2], and 12 [3]. The absolute stereochemistry (6S) of each bastadin (or its tetramethyl ester derivative) was determined by means of the Mosher-Trost method. Bastadins 10 [2] and 12 [3] were found to significantly inhibit the growth of a selection of human cancer cell lines. Bastadins 8, 10, and 12 inhibited growth of the Gram-positive opportunists Staphylococcus aureus and Enterococcus faecalis.

Original languageEnglish (US)
Pages (from-to)680-688
Number of pages9
JournalJournal of Natural Products
Volume58
Issue number5
DOIs
StatePublished - May 1995

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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