Abstract
Phakellistatin 6 (7), a trace (7.5 × 10-7% yield) constituent of the marine sponge Phakellia costata located in the Federated States of Micronesia has been found to significantly inhibit growth of certain human cancer cell lines (GI50, 0.1 to 0.01 μg/ml). The structure of phakellistatin 6 (7) was deduced as cyclo (Pro-Trp-Leu-Pro-Ile-Pro-Phe) employing a combination of MS/MS and high field (500 MHz) 2D-NMR procedures followed by chiral (all S amino acids) assignments using hydrolysis → derivatisation → chiral chromatographic techniques.
Original language | English (US) |
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Pages (from-to) | 2677-2682 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 4 |
Issue number | 22 |
DOIs | |
State | Published - Nov 1994 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry