Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5

George Pettit; Jun-Ping Xu; Zbigniew Cichacz; Michael D. Williams; Ann Christine Dorsaz; Daniel C. Brune; Michael R. Boyd; Ronald L. Cerny

doi:10.1016/S0960-894X(01)80108-6

Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5

George Pettit, Jun-Ping Xu, Zbigniew Cichacz, Michael D. Williams, Ann Christine Dorsaz, Daniel C. Brune, Michael R. Boyd, Ronald L. Cerny

Research output: Contribution to journal › Article › peer-review

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Abstract

The Federated State of Micronesia (Chuuk) marine sponge Phakellia costada has been found to contain (9.6 x 10^-6 % yield) a new human cancer cell growth inhibitor designated phakellistatin 5 (3). Structural elucidation was accomplished employing high resolution FAB tandem MS/MS and high field (500 MHz) 2D-NMR techniques. Extension of the NMR experiments over the temperature range -25 to 25°C allowed the principal solution conformation of phakellistatin 5 to be assigned (Figure 2). The absolute configuration was found to correspond to S-amino acid units except for R-Asn.

Original language	English (US)
Pages (from-to)	2091-2096
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	17
DOIs	https://doi.org/10.1016/S0960-894X(01)80108-6
State	Published - Sep 8 1994

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)80108-6

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title = "Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5",

abstract = "The Federated State of Micronesia (Chuuk) marine sponge Phakellia costada has been found to contain (9.6 x 10-6 % yield) a new human cancer cell growth inhibitor designated phakellistatin 5 (3). Structural elucidation was accomplished employing high resolution FAB tandem MS/MS and high field (500 MHz) 2D-NMR techniques. Extension of the NMR experiments over the temperature range -25 to 25°C allowed the principal solution conformation of phakellistatin 5 to be assigned (Figure 2). The absolute configuration was found to correspond to S-amino acid units except for R-Asn.",

author = "George Pettit and Jun-Ping Xu and Zbigniew Cichacz and Williams, {Michael D.} and Dorsaz, {Ann Christine} and Brune, {Daniel C.} and Boyd, {Michael R.} and Cerny, {Ronald L.}",

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AU - Pettit, George

AU - Xu, Jun-Ping

AU - Cichacz, Zbigniew

AU - Williams, Michael D.

AU - Dorsaz, Ann Christine

AU - Brune, Daniel C.

AU - Boyd, Michael R.

AU - Cerny, Ronald L.

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AB - The Federated State of Micronesia (Chuuk) marine sponge Phakellia costada has been found to contain (9.6 x 10-6 % yield) a new human cancer cell growth inhibitor designated phakellistatin 5 (3). Structural elucidation was accomplished employing high resolution FAB tandem MS/MS and high field (500 MHz) 2D-NMR techniques. Extension of the NMR experiments over the temperature range -25 to 25°C allowed the principal solution conformation of phakellistatin 5 to be assigned (Figure 2). The absolute configuration was found to correspond to S-amino acid units except for R-Asn.

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Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5

Abstract

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