Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

George Pettit; Zbigniew Cichacz; Cherry L. Herald; Feng Gao; Michael R. Boyd; Jean M. Schmidt; Ernest Hamel; Ruoli Bai

doi:10.1039/C39940001605

Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

George Pettit, Zbigniew Cichacz, Cherry L. Herald, Feng Gao, Michael R. Boyd, Jean M. Schmidt, Ernest Hamel, Ruoli Bai

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Two trace (0.7 and 2.2×10^-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.

Original language	English (US)
Pages (from-to)	1605-1606
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	13
DOIs	https://doi.org/10.1039/C39940001605
State	Published - 1994

ASJC Scopus subject areas

Molecular Medicine

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title = "Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9",

abstract = "Two trace (0.7 and 2.2×10-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.",

author = "George Pettit and Zbigniew Cichacz and Herald, {Cherry L.} and Feng Gao and Boyd, {Michael R.} and Schmidt, {Jean M.} and Ernest Hamel and Ruoli Bai",

year = "1994",

doi = "10.1039/C39940001605",

language = "English (US)",

pages = "1605--1606",

journal = "Journal of the Chemical Society D: Chemical Communications",

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T1 - Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

AU - Pettit, George

AU - Cichacz, Zbigniew

AU - Herald, Cherry L.

AU - Gao, Feng

AU - Boyd, Michael R.

AU - Schmidt, Jean M.

AU - Hamel, Ernest

AU - Bai, Ruoli

PY - 1994

Y1 - 1994

N2 - Two trace (0.7 and 2.2×10-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.

AB - Two trace (0.7 and 2.2×10-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.

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M3 - Article

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JO - Journal of the Chemical Society D: Chemical Communications

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Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

Abstract

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