Abstract
Two trace (0.7 and 2.2×10-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1605-1606 |
| Number of pages | 2 |
| Journal | Journal of the Chemical Society, Chemical Communications |
| Issue number | 13 |
| DOIs | |
| State | Published - 1994 |
ASJC Scopus subject areas
- Molecular Medicine
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Pettit, G., Cichacz, Z., Herald, C. L., Gao, F., Boyd, M. R., Schmidt, J. M., Hamel, E., & Bai, R. (1994). Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9. Journal of the Chemical Society, Chemical Communications, (13), 1605-1606. https://doi.org/10.1039/C39940001605