Abstract
Two trace (0.7 and 2.2×10-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.
Original language | English (US) |
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Pages (from-to) | 1605-1606 |
Number of pages | 2 |
Journal | Journal of the Chemical Society, Chemical Communications |
Issue number | 13 |
DOIs | |
State | Published - 1994 |
ASJC Scopus subject areas
- Molecular Medicine