Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

George Pettit, Zbigniew Cichacz, Cherry L. Herald, Feng Gao, Michael R. Boyd, Jean M. Schmidt, Ernest Hamel, Ruoli Bai

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Two trace (0.7 and 2.2×10-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.

Original languageEnglish (US)
Pages (from-to)1605-1606
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number13
DOIs
StatePublished - 1994

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Porifera
Lactones
Tubulin
Polymerization
Antineoplastic Agents
Glutamic Acid
Neoplasms

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9. / Pettit, George; Cichacz, Zbigniew; Herald, Cherry L.; Gao, Feng; Boyd, Michael R.; Schmidt, Jean M.; Hamel, Ernest; Bai, Ruoli.

In: Journal of the Chemical Society, Chemical Communications, No. 13, 1994, p. 1605-1606.

Research output: Contribution to journalArticle

Pettit, George ; Cichacz, Zbigniew ; Herald, Cherry L. ; Gao, Feng ; Boyd, Michael R. ; Schmidt, Jean M. ; Hamel, Ernest ; Bai, Ruoli. / Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9. In: Journal of the Chemical Society, Chemical Communications. 1994 ; No. 13. pp. 1605-1606.
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