Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

George Pettit, Zbigniew Cichacz, Cherry L. Herald, Feng Gao, Michael R. Boyd, Jean M. Schmidt, Ernest Hamel, Ruoli Bai

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Two trace (0.7 and 2.2×10-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.

Original languageEnglish (US)
Pages (from-to)1605-1606
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number13
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Molecular Medicine

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