Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

George Pettit; Zbigniew Cichacz; Cherry L. Herald; Feng Gao; Michael R. Boyd; Jean M. Schmidt; Ernest Hamel; Ruoli Bai

doi:10.1039/C39940001605

Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

George Pettit, Zbigniew Cichacz, Cherry L. Herald, Feng Gao, Michael R. Boyd, Jean M. Schmidt, Ernest Hamel, Ruoli Bai

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Two trace (0.7 and 2.2×10^-7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.

Original language	English (US)
Pages (from-to)	1605-1606
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	13
DOIs	https://doi.org/10.1039/C39940001605
State	Published - 1994

ASJC Scopus subject areas

Molecular Medicine

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Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9. / Pettit, George; Cichacz, Zbigniew; Herald, Cherry L.; Gao, Feng; Boyd, Michael R.; Schmidt, Jean M.; Hamel, Ernest; Bai, Ruoli.

In: Journal of the Chemical Society, Chemical Communications, No. 13, 1994, p. 1605-1606.

Research output: Contribution to journal › Article › peer-review

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AU - Schmidt, Jean M.

AU - Hamel, Ernest

AU - Bai, Ruoli

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Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

Abstract

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UN SDGs

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