@article{6ab9b937a4fa4dee86243d6a7d546a15,
title = "Antineoplastic Agents 293. The Exceptional Human Cancer Cell Growth Inhibitors Spongistatins 6 And 71",
abstract = "A twenty year investigation of the South African marine sponge Spirastrella spinispirulifera (Carter, 1879) for antineoplastic constituents has now led to discovery of spongistatin 6 (le) and 7 (2b) in 3.5 × 10{"}7% and 2.2 × 107% yields. Structural elucidations were based on detailed analyses of high field (400 and 500 MHz) 2D-NMR and high resolution mass spectra. Spongistatins 6 and 7 were exceptionally potent against a subset of human cancer cell lines in the NCI screening panel which are characteristically sensitive to cellular microtubule interactive antimitotics.",
keywords = "Antineoplastic, NCI human cancer cell lines, Spirastrella spinispirulifera, spongistatin",
author = "George Pettit and Herald, {C. L.} and Zbigniew Cichacz and {Gao Feng}, Feng and Boyd, {M. R.} and Christie, {N. G.} and Schmidt, {J. M.}",
note = "Funding Information: The very necessary financial assistance was provided by Outstanding Investigator Grant CA 44344-01A1-05 awarded by the Division of Cancer Treatment, National Cancer Institute, DHHS; the Arizona Disease Control Research Commission; the Robert B. Dalton Endowment Fund; Herbert and Diane Cummings; The Nathan Cummings Foundation, Inc. and Gary L. Tooker. We are also pleased to thank for other helpful assistance, Drs. Ronald L. Cerny and Fiona Hogan-Pierson, Matthew Suffness, Ms. Betty J. Abbott, Mrs. Kim M. Weiss, Mr. Lee Williams, the U. S. National Science Foundation (Grants CHE-8409644 and BBS-88-04992)a nd the Midwest Center for Mass Spectrometry, the University of Nebraska-Lincoln (NSF Regional Instrumentation Grants CHE-8620177 and DIR9017262).",
year = "1993",
month = dec,
day = "1",
doi = "10.1080/10575639308043871",
language = "English (US)",
volume = "3",
pages = "239--244",
journal = "Natural Product Letters",
issn = "1057-5634",
publisher = "Taylor and Francis Ltd.",
number = "4",
}