Antineoplastic Agents 293. The Exceptional Human Cancer Cell Growth Inhibitors Spongistatins 6 And 71

George Pettit, C. L. Herald, Zbigniew Cichacz, Feng Gao Feng, M. R. Boyd, N. G. Christie, J. M. Schmidt

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

A twenty year investigation of the South African marine sponge Spirastrella spinispirulifera (Carter, 1879) for antineoplastic constituents has now led to discovery of spongistatin 6 (le) and 7 (2b) in 3.5 × 10"7% and 2.2 × 107% yields. Structural elucidations were based on detailed analyses of high field (400 and 500 MHz) 2D-NMR and high resolution mass spectra. Spongistatins 6 and 7 were exceptionally potent against a subset of human cancer cell lines in the NCI screening panel which are characteristically sensitive to cellular microtubule interactive antimitotics.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalNatural Product Letters
Volume3
Issue number4
DOIs
StatePublished - Dec 1 1993

Keywords

  • Antineoplastic
  • NCI human cancer cell lines
  • Spirastrella spinispirulifera
  • spongistatin

ASJC Scopus subject areas

  • Molecular Medicine

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    Pettit, G., Herald, C. L., Cichacz, Z., Gao Feng, F., Boyd, M. R., Christie, N. G., & Schmidt, J. M. (1993). Antineoplastic Agents 293. The Exceptional Human Cancer Cell Growth Inhibitors Spongistatins 6 And 71. Natural Product Letters, 3(4), 239-244. https://doi.org/10.1080/10575639308043871