Antineoplastic agents. 206. Structure of the cytostatic macrocyclic lactone combretastatin D-2

Sheo Bux Singh, George Pettit

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The South African tree Combretum caffrum (Combretaceae) has been found to contain two new and cytostatic (P388 lymphocytic leukemia) macrocyclic lactones designated combretastatin D-l (1, ED503.3 μg/mL) and D-2 (2, ED505.2 μg/mL). With the X-ray crystal structure of combretastatin D-l (1) serving as an unequivocal reference point 13C NMR and high field (400 MHz)1H NMR spectral techniques were employed to assign structure 2 to combretastatin D-2.

Original languageEnglish (US)
Pages (from-to)2797-2800
Number of pages4
JournalJournal of Organic Chemistry
Volume55
Issue number9
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Organic Chemistry

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