Antineoplastic agents. 206. Structure of the cytostatic macrocyclic lactone combretastatin D-2

Sheo Bux Singh; George Pettit

doi:10.1021/jo00296a043

Antineoplastic agents. 206. Structure of the cytostatic macrocyclic lactone combretastatin D-2

Sheo Bux Singh, George Pettit

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Abstract

The South African tree Combretum caffrum (Combretaceae) has been found to contain two new and cytostatic (P388 lymphocytic leukemia) macrocyclic lactones designated combretastatin D-l (1, ED₅₀3.3 μg/mL) and D-2 (2, ED₅₀5.2 μg/mL). With the X-ray crystal structure of combretastatin D-l (1) serving as an unequivocal reference point 13C NMR and high field (400 MHz)¹H NMR spectral techniques were employed to assign structure 2 to combretastatin D-2.

Original language	English (US)
Pages (from-to)	2797-2800
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	55
Issue number	9
DOIs	https://doi.org/10.1021/jo00296a043
State	Published - 1990

ASJC Scopus subject areas

Organic Chemistry

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title = "Antineoplastic agents. 206. Structure of the cytostatic macrocyclic lactone combretastatin D-2",

abstract = "The South African tree Combretum caffrum (Combretaceae) has been found to contain two new and cytostatic (P388 lymphocytic leukemia) macrocyclic lactones designated combretastatin D-l (1, ED503.3 μg/mL) and D-2 (2, ED505.2 μg/mL). With the X-ray crystal structure of combretastatin D-l (1) serving as an unequivocal reference point 13C NMR and high field (400 MHz)1H NMR spectral techniques were employed to assign structure 2 to combretastatin D-2.",

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year = "1990",

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AU - Singh, Sheo Bux

AU - Pettit, George

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N2 - The South African tree Combretum caffrum (Combretaceae) has been found to contain two new and cytostatic (P388 lymphocytic leukemia) macrocyclic lactones designated combretastatin D-l (1, ED503.3 μg/mL) and D-2 (2, ED505.2 μg/mL). With the X-ray crystal structure of combretastatin D-l (1) serving as an unequivocal reference point 13C NMR and high field (400 MHz)1H NMR spectral techniques were employed to assign structure 2 to combretastatin D-2.

AB - The South African tree Combretum caffrum (Combretaceae) has been found to contain two new and cytostatic (P388 lymphocytic leukemia) macrocyclic lactones designated combretastatin D-l (1, ED503.3 μg/mL) and D-2 (2, ED505.2 μg/mL). With the X-ray crystal structure of combretastatin D-l (1) serving as an unequivocal reference point 13C NMR and high field (400 MHz)1H NMR spectral techniques were employed to assign structure 2 to combretastatin D-2.

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IS - 9

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Antineoplastic agents. 206. Structure of the cytostatic macrocyclic lactone combretastatin D-2

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