Antineoplastic Agents. 190. Isolation and Structure of the Cyclodepsipeptide Dolastatin 141

George Pettit; Yoshiaki Kamano; Cherry L. Herald; Claude Dufresne; Robert B. Bates; Jean M. Schmidt; Ronald L. Cerny; Haruhisa Kizu

doi:10.1021/jo00297a001

Antineoplastic Agents. 190. Isolation and Structure of the Cyclodepsipeptide Dolastatin 14¹

George Pettit, Yoshiaki Kamano, Cherry L. Herald, Claude Dufresne, Robert B. Bates, Jean M. Schmidt, Ronald L. Cerny, Haruhisa Kizu

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

: The Indian Ocean sea hare Dolabella auricularia has been found to contain a novel cytostatic (PS ED50 0.022 µg/mL) cyclodepsipeptide designated dolastatin 14. Structure 1 was assigned dolastatin 14 and was deduced primarily by a series of 2D NMR studies at high field (400 MHz).

Original language	English (US)
Pages (from-to)	2989-2990
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	55
Issue number	10
DOIs	https://doi.org/10.1021/jo00297a001
State	Published - 1990

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo00297a001

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title = "Antineoplastic Agents. 190. Isolation and Structure of the Cyclodepsipeptide Dolastatin 141",

abstract = ": The Indian Ocean sea hare Dolabella auricularia has been found to contain a novel cytostatic (PS ED50 0.022 µg/mL) cyclodepsipeptide designated dolastatin 14. Structure 1 was assigned dolastatin 14 and was deduced primarily by a series of 2D NMR studies at high field (400 MHz).",

author = "George Pettit and Yoshiaki Kamano and Herald, {Cherry L.} and Claude Dufresne and Bates, {Robert B.} and Schmidt, {Jean M.} and Cerny, {Ronald L.} and Haruhisa Kizu",

year = "1990",

doi = "10.1021/jo00297a001",

language = "English (US)",

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journal = "Journal of Organic Chemistry",

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T1 - Antineoplastic Agents. 190. Isolation and Structure of the Cyclodepsipeptide Dolastatin 141

AU - Pettit, George

AU - Kamano, Yoshiaki

AU - Herald, Cherry L.

AU - Dufresne, Claude

AU - Bates, Robert B.

AU - Schmidt, Jean M.

AU - Cerny, Ronald L.

AU - Kizu, Haruhisa

PY - 1990

Y1 - 1990

N2 - : The Indian Ocean sea hare Dolabella auricularia has been found to contain a novel cytostatic (PS ED50 0.022 µg/mL) cyclodepsipeptide designated dolastatin 14. Structure 1 was assigned dolastatin 14 and was deduced primarily by a series of 2D NMR studies at high field (400 MHz).

AB - : The Indian Ocean sea hare Dolabella auricularia has been found to contain a novel cytostatic (PS ED50 0.022 µg/mL) cyclodepsipeptide designated dolastatin 14. Structure 1 was assigned dolastatin 14 and was deduced primarily by a series of 2D NMR studies at high field (400 MHz).

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DO - 10.1021/jo00297a001

M3 - Article

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JO - Journal of Organic Chemistry

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IS - 10

ER -

Antineoplastic Agents. 190. Isolation and Structure of the Cyclodepsipeptide Dolastatin 14¹

Abstract

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