Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the south american lychnophora antillana1

George Pettit; Delbert L. Herald; Gordon M. Cragg; John A. Rideout; Peter Brown

doi:10.1021/np50068a017

Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the south american lychnophora antillana¹

George Pettit, Delbert L. Herald, Gordon M. Cragg, John A. Rideout, Peter Brown

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH₂Cl₂/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED₅₀ 2.0 and 0.19 μg/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.

Original language	English (US)
Pages (from-to)	382-390
Number of pages	9
Journal	Journal of Natural Products
Volume	53
Issue number	2
DOIs	https://doi.org/10.1021/np50068a017
State	Published - 1990

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50068a017

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abstract = "Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 μg/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.",

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T1 - Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the south american lychnophora antillana1

AU - Pettit, George

AU - Herald, Delbert L.

AU - Cragg, Gordon M.

AU - Rideout, John A.

AU - Brown, Peter

PY - 1990

Y1 - 1990

N2 - Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 μg/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.

AB - Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 μg/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.

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Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the south american lychnophora antillana¹

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