Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the south american lychnophora antillana1

George Pettit, Delbert L. Herald, Gordon M. Cragg, John A. Rideout, Peter Brown

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 μg/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.

Original languageEnglish (US)
Pages (from-to)382-390
Number of pages9
JournalJournal of Natural Products
Volume53
Issue number2
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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