Antineoplastic agents, 177.1 isolation and structure of phyllanthostatin 6

George Pettit, Daniel E. Schaufelberger, Ronald A. Nieman, Claude Dufresne, J. A. Saenz-Renauld

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The isolation and structural elucidation of a new Phyllanthus glycoside, phyllanthostatin 6 [7], was summarized. Phyllanthostatin 6 [7] was isolated from the roots of Phyllanthus acuminatus (Euphorbiaceae) and was found to inhibit (ED50 = 0.35 µg/ml) growth of the murine P-388 lymphocytic leukemia cell line. Two other new constituents were shown to be didesacetylphyllanthostatin 3 [9] and descinnamoylphyllanthocindiol [10]. Structure determinations were achieved employing hrfabms and 2D-nmr spectroscopy. Application of an hplc separation technique to the Phyllanthus glycosides and development of a new isolation procedure for the major antineoplastic constituent, phyllanthoside [1], are also described.

Original languageEnglish (US)
Pages (from-to)1406-1413
Number of pages8
JournalJournal of Natural Products
Volume53
Issue number6
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Pettit, G., Schaufelberger, D. E., Nieman, R. A., Dufresne, C., & Saenz-Renauld, J. A. (1990). Antineoplastic agents, 177.1 isolation and structure of phyllanthostatin 6. Journal of Natural Products, 53(6), 1406-1413. https://doi.org/10.1021/np50072a002