Antineoplastic agents, 162.1 zephyranthes candida

George Pettit, Gordon M. Cragg, Sheo Bux Singh, James A. Duke, Dennis L. Doubek

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 X 10-3 μ-g/ml.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalJournal of Natural Products
Volume53
Issue number1
DOIs
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Pettit, G., Cragg, G. M., Singh, S. B., Duke, J. A., & Doubek, D. L. (1990). Antineoplastic agents, 162.1 zephyranthes candida. Journal of Natural Products, 53(1), 176-178. https://doi.org/10.1021/np50067a026