Antineoplastic agents, 162. Zephyranthes candida

George Pettit, Gordon M. Cragg, Sheo Bux Singh, James A. Duke, Dennis L. Doubek

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 × 10-3 μg/ml.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalJournal of Natural Products
Volume53
Issue number1
StatePublished - 1990

Fingerprint

Zephyranthes
lymphocytic leukemia
Candida
antineoplastic agents
Cytostatic Agents
Antineoplastic Agents
medicinal plants
bioassays
Lymphoid Leukemia
Bioassay
extracts
Medicinal Plants
Biological Assay
Amaryllidaceae

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Pettit, G., Cragg, G. M., Singh, S. B., Duke, J. A., & Doubek, D. L. (1990). Antineoplastic agents, 162. Zephyranthes candida. Journal of Natural Products, 53(1), 176-178.

Antineoplastic agents, 162. Zephyranthes candida. / Pettit, George; Cragg, Gordon M.; Singh, Sheo Bux; Duke, James A.; Doubek, Dennis L.

In: Journal of Natural Products, Vol. 53, No. 1, 1990, p. 176-178.

Research output: Contribution to journalArticle

Pettit, G, Cragg, GM, Singh, SB, Duke, JA & Doubek, DL 1990, 'Antineoplastic agents, 162. Zephyranthes candida', Journal of Natural Products, vol. 53, no. 1, pp. 176-178.
Pettit G, Cragg GM, Singh SB, Duke JA, Doubek DL. Antineoplastic agents, 162. Zephyranthes candida. Journal of Natural Products. 1990;53(1):176-178.
Pettit, George ; Cragg, Gordon M. ; Singh, Sheo Bux ; Duke, James A. ; Doubek, Dennis L. / Antineoplastic agents, 162. Zephyranthes candida. In: Journal of Natural Products. 1990 ; Vol. 53, No. 1. pp. 176-178.
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