Abstract
The bulbs of Pancratium littorale collected in Hawaii were found to contain a new phenanthridone biosynthetic product designated pancratistatin (4a) that proved to be effective (38-106% life extension at 0.75-12.5 mg/kg dose levels) against the murine P-388 lymphocytic leukemia. Pancratistatin also markedly inhibited (ED50, 0.01 μg/ml) growth of the P-388 in vitro cell line and in vivo murine M-5076 ovary sarcoma (53-84% life extension at 0.38-3.0 mg/kg). An X-ray crystal structure determination of pancratistatin monomethyl ether (4c) and a detailed high resolution (400 MHz) nmr study of pancratistatin and its pentaacetate (4b) completed assignment of structure 4a. Companion antineoplastic constituents of P. littorale were found to be narciclasine (2c) and its 7-deoxy derivative (2a). The structure of 7-deoxynarciclasine (2c) was also confirmed by an X-ray crystallographic analysis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 995-1002 |
| Number of pages | 8 |
| Journal | Journal of Natural Products |
| Volume | 49 |
| Issue number | 6 |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Antineoplastic agents, 120. Pancratium littorale. / Pettit, George; Gaddamidi, Venkatswamy; Herald, Delbert L.; Singh, Sheo Bux; Cragg, Gordon M.; Schmidt, Jean M.; Boettner, Fred E.; Williams, M.; Sagawa, Yoneo.
In: Journal of Natural Products, Vol. 49, No. 6, 1986, p. 995-1002.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antineoplastic agents, 120. Pancratium littorale
AU - Pettit, George
AU - Gaddamidi, Venkatswamy
AU - Herald, Delbert L.
AU - Singh, Sheo Bux
AU - Cragg, Gordon M.
AU - Schmidt, Jean M.
AU - Boettner, Fred E.
AU - Williams, M.
AU - Sagawa, Yoneo
PY - 1986
Y1 - 1986
N2 - The bulbs of Pancratium littorale collected in Hawaii were found to contain a new phenanthridone biosynthetic product designated pancratistatin (4a) that proved to be effective (38-106% life extension at 0.75-12.5 mg/kg dose levels) against the murine P-388 lymphocytic leukemia. Pancratistatin also markedly inhibited (ED50, 0.01 μg/ml) growth of the P-388 in vitro cell line and in vivo murine M-5076 ovary sarcoma (53-84% life extension at 0.38-3.0 mg/kg). An X-ray crystal structure determination of pancratistatin monomethyl ether (4c) and a detailed high resolution (400 MHz) nmr study of pancratistatin and its pentaacetate (4b) completed assignment of structure 4a. Companion antineoplastic constituents of P. littorale were found to be narciclasine (2c) and its 7-deoxy derivative (2a). The structure of 7-deoxynarciclasine (2c) was also confirmed by an X-ray crystallographic analysis.
AB - The bulbs of Pancratium littorale collected in Hawaii were found to contain a new phenanthridone biosynthetic product designated pancratistatin (4a) that proved to be effective (38-106% life extension at 0.75-12.5 mg/kg dose levels) against the murine P-388 lymphocytic leukemia. Pancratistatin also markedly inhibited (ED50, 0.01 μg/ml) growth of the P-388 in vitro cell line and in vivo murine M-5076 ovary sarcoma (53-84% life extension at 0.38-3.0 mg/kg). An X-ray crystal structure determination of pancratistatin monomethyl ether (4c) and a detailed high resolution (400 MHz) nmr study of pancratistatin and its pentaacetate (4b) completed assignment of structure 4a. Companion antineoplastic constituents of P. littorale were found to be narciclasine (2c) and its 7-deoxy derivative (2a). The structure of 7-deoxynarciclasine (2c) was also confirmed by an X-ray crystallographic analysis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022884334&partnerID=8YFLogxK
M3 - Article
C2 - 3572427
AN - SCOPUS:0022884334
VL - 49
SP - 995
EP - 1002
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 6
ER -