Antineoplastic agents, 120. Pancratium littorale

George Pettit, Venkatswamy Gaddamidi, Delbert L. Herald, Sheo Bux Singh, Gordon M. Cragg, Jean M. Schmidt, Fred E. Boettner, M. Williams, Yoneo Sagawa

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

The bulbs of Pancratium littorale collected in Hawaii were found to contain a new phenanthridone biosynthetic product designated pancratistatin (4a) that proved to be effective (38-106% life extension at 0.75-12.5 mg/kg dose levels) against the murine P-388 lymphocytic leukemia. Pancratistatin also markedly inhibited (ED50, 0.01 μg/ml) growth of the P-388 in vitro cell line and in vivo murine M-5076 ovary sarcoma (53-84% life extension at 0.38-3.0 mg/kg). An X-ray crystal structure determination of pancratistatin monomethyl ether (4c) and a detailed high resolution (400 MHz) nmr study of pancratistatin and its pentaacetate (4b) completed assignment of structure 4a. Companion antineoplastic constituents of P. littorale were found to be narciclasine (2c) and its 7-deoxy derivative (2a). The structure of 7-deoxynarciclasine (2c) was also confirmed by an X-ray crystallographic analysis.

Original languageEnglish (US)
Pages (from-to)995-1002
Number of pages8
JournalJournal of Natural Products
Volume49
Issue number6
StatePublished - 1986

Fingerprint

Pancratium
antineoplastic agents
Antineoplastic Agents
X-radiation
lymphocytic leukemia
mice
sarcoma
crystal structure
Life Expectancy
Hawaii
bulbs
ethers
chemical derivatives
cell lines
X-Rays
Lymphoid Leukemia
X rays
dosage
Sarcoma
Ether

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Pettit, G., Gaddamidi, V., Herald, D. L., Singh, S. B., Cragg, G. M., Schmidt, J. M., ... Sagawa, Y. (1986). Antineoplastic agents, 120. Pancratium littorale. Journal of Natural Products, 49(6), 995-1002.

Antineoplastic agents, 120. Pancratium littorale. / Pettit, George; Gaddamidi, Venkatswamy; Herald, Delbert L.; Singh, Sheo Bux; Cragg, Gordon M.; Schmidt, Jean M.; Boettner, Fred E.; Williams, M.; Sagawa, Yoneo.

In: Journal of Natural Products, Vol. 49, No. 6, 1986, p. 995-1002.

Research output: Contribution to journalArticle

Pettit, G, Gaddamidi, V, Herald, DL, Singh, SB, Cragg, GM, Schmidt, JM, Boettner, FE, Williams, M & Sagawa, Y 1986, 'Antineoplastic agents, 120. Pancratium littorale', Journal of Natural Products, vol. 49, no. 6, pp. 995-1002.
Pettit G, Gaddamidi V, Herald DL, Singh SB, Cragg GM, Schmidt JM et al. Antineoplastic agents, 120. Pancratium littorale. Journal of Natural Products. 1986;49(6):995-1002.
Pettit, George ; Gaddamidi, Venkatswamy ; Herald, Delbert L. ; Singh, Sheo Bux ; Cragg, Gordon M. ; Schmidt, Jean M. ; Boettner, Fred E. ; Williams, M. ; Sagawa, Yoneo. / Antineoplastic agents, 120. Pancratium littorale. In: Journal of Natural Products. 1986 ; Vol. 49, No. 6. pp. 995-1002.
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