Antineoplastic agents, 120. pancratium littorale

George Pettit, Venkatswamy Gaddamidi, Delbert L. Herald, Sheo Bux Singh, Gordon M. Cragg, Jean M. Schmidt, Fred E. Boettner, M. Williams, Yoneo Sagawa

Research output: Contribution to journalArticle

200 Scopus citations

Abstract

The bulbs of Pancratium littorale collected in Hawaii were found to contain a new phenanthridone biosynthetic product designated pancratistatin (4a) that proved to be effective (38-106% life extension at 0.75-12.5 mg/kg dose levels) against the murine P-388 lymphocytic leukemia. Pancratistatin also markedly inhibited (ED50, 0.01 μg/ml) growth of the P-388 in vitro cell line and in vivo murine M-5076 ovary sarcoma (53-84% life extension at 0.38-3.0 mg/kg). An X-ray crystal structure determination of pancratistatin monomethyl ether (4c) and a detailed high resolution (400 MHz) nmr study of pancratistatin and its pentaacetate (4b) completed assignment of structure 4a. Companion antineoplastic constituents of P. littorale were found to be narciclasine (2c) and its 7-deoxy derivative (2a). The structure of 7-deoxynarciclasine (2c) was also confirmed by an X-ray crystallographic analysis.

Original languageEnglish (US)
Pages (from-to)995-1002
Number of pages8
JournalJournal of Natural Products
Volume49
Issue number6
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Antineoplastic agents, 120. pancratium littorale'. Together they form a unique fingerprint.

  • Cite this

    Pettit, G., Gaddamidi, V., Herald, D. L., Singh, S. B., Cragg, G. M., Schmidt, J. M., Boettner, F. E., Williams, M., & Sagawa, Y. (1986). Antineoplastic agents, 120. pancratium littorale. Journal of Natural Products, 49(6), 995-1002. https://doi.org/10.1021/np50048a005