Antineoplastic Agents, 116. An Evaluation of the Marine Ascidian Aplidium Californicum

George Pettit; John E. Leet; Cherry L. Herald; Yoshiaki Kamano; Dennis L. Doubek

doi:10.1021/np50044a006

Antineoplastic Agents, 116. An Evaluation of the Marine Ascidian Aplidium Californicum

George Pettit, John E. Leet, Cherry L. Herald, Yoshiaki Kamano, Dennis L. Doubek

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The antineoplastic constituents of the marine ascidian Aplidium californicum were found to be bryostatins 4 and 5. Bioassay-directed isolation procedures using the National Cancer Institute's P-388 lymphocytic leukemia system led to the bryostatins. The probable symbiotic relationship between A. californicum and the bryozoan Bugula neritina was discussed.

Original language	English (US)
Pages (from-to)	231-235
Number of pages	5
Journal	Journal of Natural Products
Volume	49
Issue number	2
DOIs	https://doi.org/10.1021/np50044a006
State	Published - 1986

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50044a006

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abstract = "The antineoplastic constituents of the marine ascidian Aplidium californicum were found to be bryostatins 4 and 5. Bioassay-directed isolation procedures using the National Cancer Institute's P-388 lymphocytic leukemia system led to the bryostatins. The probable symbiotic relationship between A. californicum and the bryozoan Bugula neritina was discussed.",

author = "George Pettit and Leet, {John E.} and Herald, {Cherry L.} and Yoshiaki Kamano and Doubek, {Dennis L.}",

year = "1986",

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AU - Kamano, Yoshiaki

AU - Doubek, Dennis L.

PY - 1986

Y1 - 1986

N2 - The antineoplastic constituents of the marine ascidian Aplidium californicum were found to be bryostatins 4 and 5. Bioassay-directed isolation procedures using the National Cancer Institute's P-388 lymphocytic leukemia system led to the bryostatins. The probable symbiotic relationship between A. californicum and the bryozoan Bugula neritina was discussed.

AB - The antineoplastic constituents of the marine ascidian Aplidium californicum were found to be bryostatins 4 and 5. Bioassay-directed isolation procedures using the National Cancer Institute's P-388 lymphocytic leukemia system led to the bryostatins. The probable symbiotic relationship between A. californicum and the bryozoan Bugula neritina was discussed.

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Antineoplastic Agents, 116. An Evaluation of the Marine Ascidian Aplidium Californicum

Abstract

ASJC Scopus subject areas

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