Antineoplastic agents, 103. the isolation and structure of hypoestestatins 1 and 2 from the east african hypoestes verticillaris1

George Pettit, Animesh Goswami, Gordon M. Cragg, Jean M. Schmidt, Ji Chun Zou

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The East African shrub Hypoëstes verticillaris representing a heretofore chemically unexplored Acanthaceae genus has been found to contain two new cell growth inhibitory (murine P-388 lymphocytic leukemia) phenanthroindolizidine alkaloids termed hypoestestatin 1 (la) and hypoestestatin 2 (lb). Both substances were found to markedly inhibit growth of the murine P-388 cell line (ED50= 10-5 μ/ml). The structures of hypoestestatins 1 and 2 were assigned primarily on the basis of results from extensive spectral studies.

Original languageEnglish (US)
Pages (from-to)913-919
Number of pages7
JournalJournal of Natural Products
Volume47
Issue number6
DOIs
StatePublished - Jan 1984

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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