Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris

George Pettit, Animesh Goswami, Gordon M. Cragg, Jean M. Schmidt, Ji Chun Zou

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The East African shrub Hypoëstes verticillaris representing a heretofore chemically unexplored Acanthaceae genus has been found to contain two new cell growth inhibitory (murine P-388 lymphocytic leukemia) phenanthroindolizidine alkaloids termed hypoestestatin 1 (1a) and hypoestestatin 2 (1b). Both substances were found to markedly inhibit growth of the murine P-388 cell line (ED50=10-5 μg/ml). The structures of hypoestestatins 1 and 2 were assigned primarily on the basis of results from extensive spectral studies.

Original languageEnglish (US)
Pages (from-to)913-919
Number of pages7
JournalJournal of Natural Products
Volume47
Issue number6
StatePublished - 1984

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antineoplastic agents
Antineoplastic Agents
Acanthaceae
Lymphoid Leukemia
lymphocytic leukemia
mice
Cell growth
Growth
Alkaloids
cell growth
alkaloids
shrubs
Cells
cell lines
Cell Line
hypoestestatin 1
hypoestestatin 2
phenanthroindolizidine

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris. / Pettit, George; Goswami, Animesh; Cragg, Gordon M.; Schmidt, Jean M.; Zou, Ji Chun.

In: Journal of Natural Products, Vol. 47, No. 6, 1984, p. 913-919.

Research output: Contribution to journalArticle

Pettit, George ; Goswami, Animesh ; Cragg, Gordon M. ; Schmidt, Jean M. ; Zou, Ji Chun. / Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris. In: Journal of Natural Products. 1984 ; Vol. 47, No. 6. pp. 913-919.
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