TY - JOUR
T1 - Antimitochondrial Antibody-Negative Primary Biliary Cirrhosis
AU - Mendes, Flavia
AU - Lindor, Keith D.
PY - 2008/6
Y1 - 2008/6
N2 - There is a subset of patients who have biochemical and histologic features consistent with primary biliary cirrhosis (PBC) who lack antimitochondrial antibodies (AMA). This entity is usually referred to as AMA-negative PBC or alternatively autoimmune cholangitis. Patients who have AMA-negative PBC are believed to have a similar clinical course, response to treatment, and prognosis as their AMA-positive counterparts. As more sensitive and specific serologic tests are developed to detect serum AMA, it is possible we may find that these patients initially believed to be AMA-negative are indeed AMA-positive, suggesting a single disease process.
AB - There is a subset of patients who have biochemical and histologic features consistent with primary biliary cirrhosis (PBC) who lack antimitochondrial antibodies (AMA). This entity is usually referred to as AMA-negative PBC or alternatively autoimmune cholangitis. Patients who have AMA-negative PBC are believed to have a similar clinical course, response to treatment, and prognosis as their AMA-positive counterparts. As more sensitive and specific serologic tests are developed to detect serum AMA, it is possible we may find that these patients initially believed to be AMA-negative are indeed AMA-positive, suggesting a single disease process.
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U2 - 10.1016/j.gtc.2008.02.006
DO - 10.1016/j.gtc.2008.02.006
M3 - Review article
C2 - 18499032
AN - SCOPUS:43549100421
SN - 0889-8553
VL - 37
SP - 479
EP - 484
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 2
ER -