Antimitochondrial Antibody-Negative Primary Biliary Cirrhosis

Flavia Mendes, Keith Lindor

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

There is a subset of patients who have biochemical and histologic features consistent with primary biliary cirrhosis (PBC) who lack antimitochondrial antibodies (AMA). This entity is usually referred to as AMA-negative PBC or alternatively autoimmune cholangitis. Patients who have AMA-negative PBC are believed to have a similar clinical course, response to treatment, and prognosis as their AMA-positive counterparts. As more sensitive and specific serologic tests are developed to detect serum AMA, it is possible we may find that these patients initially believed to be AMA-negative are indeed AMA-positive, suggesting a single disease process.

Original languageEnglish (US)
Pages (from-to)479-484
Number of pages6
JournalGastroenterology Clinics of North America
Volume37
Issue number2
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Biliary Liver Cirrhosis
Antibodies
Cholangitis
Serologic Tests
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Antimitochondrial Antibody-Negative Primary Biliary Cirrhosis. / Mendes, Flavia; Lindor, Keith.

In: Gastroenterology Clinics of North America, Vol. 37, No. 2, 06.2008, p. 479-484.

Research output: Contribution to journalArticle

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