Antigen-specific production of colony-stimulating factors by listeria monocytogenes-immune, l3t4-positive cells

D. Mitchell Magee, Edward J. Wing, Edward J. Wing

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We investigated production of colony-stimulating factors by Listeria monocytogenes-\m-mune spleen cells. Levels of total colony-stimulating factors in supernatants from antigen-stimulated immune cells were increased two-to fourfold over those in supernatants from nonimmune cells. Immune supernatants primarily induced formation of granulocyte colonies, whereas nonimmurfe supernatants induced formation of macrophage colonies. Immune supernatants had two-to 10-fold higher levels of macrophage colony-stimulating factor, as determined by radioimmunoassay, and higher levels of interleukin-3 and possibly granulocyte-macrophage colony-stimulating factor, as determined by factor-dependent cell line growth, than did nonimmune supernatants. Using enrichment and depletion techniques we showed that L3T4-positive T lymphocytes were responsible for most of the colony-stimulating factor production in the immune reaction.

Original languageEnglish (US)
Pages (from-to)941-949
Number of pages9
JournalJournal of Infectious Diseases
Volume157
Issue number5
DOIs
StatePublished - May 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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