Anticancer activities of (-)-epigallocatechin-3-gallate encapsulated nanoliposomes in MCF7 breast cancer cells

Rita Castillo Cohen De Pace, Xinli Liu, Ming Sun, Shufang Nie, Jia Zhang, Qingsong Cai, Weimin Gao, Xuan Pan, Zhaoyang Fan, Shu Wang

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

The chemopreventive actions exerted by green tea are thought to be due to its major polyphenol, (-)-epigallocatechin-3-gallate (EGCG). However, the low level of stability and bioavailability in the body makes administering EGCG at chemopreventive doses unrealistic. We synthesized EGCG encapsulated chitosan-coated nanoliposomes (CSLIPO-EGCG), and observed their antiproliferative and proapoptotic effect in MCF7 breast cancer cells. CSLIPO-EGCG significantly enhanced EGCG stability, improved sustained release, increased intracellular EGCG content in MCF7 cells, induced apoptosis of MCF7 cells, and inhibited MCF7 cell proliferation compared to native EGCG and void CSLIPO. The CSLIPO-EGCG retained its antiproliferative and proapoptotic effectiveness at 10μM or lower, at which native EGCG does not have any beneficial effects. This study portends a potential breakthrough in the prevention or even treatment of breast cancer by using biocompatible and biodegradable CSLIPO-EGCG with enhanced chemopreventive efficacy and minimized immunogenicity and side-effects.

Original languageEnglish (US)
Pages (from-to)187-196
Number of pages10
JournalJournal of Liposome Research
Volume23
Issue number3
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • Apoptosis
  • Breast cancer
  • EGCG
  • Nanoliposomes
  • Viability

ASJC Scopus subject areas

  • Pharmaceutical Science

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