TY - JOUR
T1 - Antibiotic and pesticide susceptibility and the Anthropocene operating space
AU - Living with Resistance project
AU - Jørgensen, Peter Søgaard
AU - Aktipis, C Athena
AU - Brown, Zachary
AU - Carrière, Yves
AU - Downes, Sharon
AU - Dunn, Robert R.
AU - Epstein, Graham
AU - Frisvold, George B.
AU - Hawthorne, David
AU - Gröhn, Yrjö T.
AU - Gujar, Govind Tikaramsa
AU - Jasovský, Dušan
AU - Klein, Eili Y.
AU - Klein, Franziska
AU - Lhermie, Guillaume
AU - Mota-Sanchez, David
AU - Omoto, Celso
AU - Schlüter, Maja
AU - Scott, H. Morgan
AU - Wernli, Didier
AU - Carroll, Scott P.
N1 - Funding Information:
This is a product of the Living with Resistance project supported by the National Socio-Environmental Synthesis Center (SESYNC) under funding received from the National Science Foundation DBI-1639145 and led by P.S.J. and S.P.C. We thank everyone who contributed to the four project meetings in 2016 and 2017. P.S.J. acknowledges funding from the Carlsberg foundation CF14-1050 and CF15-0988, FORMAS 2016-00451 and the Erling-Persson Family programme.
Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Rising levels of antimicrobial and pesticide resistance increasingly undermine human health and systems for biomass production, and emphasize the sustainability challenge of preserving organisms susceptible to these biocides. In this Review, we introduce key concepts and examine dynamics of biocide susceptibility that must be governed to address this challenge. We focus on the impact of biocides on the capacity of susceptible organisms to prevent spread of resistance, and we then review how biocide use affects a broader suite of ecosystem services. Finally, we introduce and assess the state of what we term the Anthropocene operating space of biocide susceptibility, a framework for assessing the potential of antibiotic and pesticide resistance to undermine key functions of human society. Based on current trends in antibiotic, insecticide and herbicide resistance, we conclude that the states of all six assessed variables are beyond safe zones, with three variables surpassed regionally or globally.
AB - Rising levels of antimicrobial and pesticide resistance increasingly undermine human health and systems for biomass production, and emphasize the sustainability challenge of preserving organisms susceptible to these biocides. In this Review, we introduce key concepts and examine dynamics of biocide susceptibility that must be governed to address this challenge. We focus on the impact of biocides on the capacity of susceptible organisms to prevent spread of resistance, and we then review how biocide use affects a broader suite of ecosystem services. Finally, we introduce and assess the state of what we term the Anthropocene operating space of biocide susceptibility, a framework for assessing the potential of antibiotic and pesticide resistance to undermine key functions of human society. Based on current trends in antibiotic, insecticide and herbicide resistance, we conclude that the states of all six assessed variables are beyond safe zones, with three variables surpassed regionally or globally.
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U2 - 10.1038/s41893-018-0164-3
DO - 10.1038/s41893-018-0164-3
M3 - Review article
AN - SCOPUS:85056454985
SN - 2398-9629
VL - 1
SP - 632
EP - 641
JO - Nature Sustainability
JF - Nature Sustainability
IS - 11
ER -