Antibacterial activity of reduced iron clay against pathogenic bacteria associated with wound infections

Katherine M. Caflisch, Suzannah M. Schmidt-Malan, Jayawant N. Mandrekar, Melissa J. Karau, Jonathan P. Nicklas, Lynda Williams, Robin Patel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Clay is a substance historically utilized by indigenous cultures for the treatment of superficial wound infections. This study evaluated the effects of a recently identified clay – OMT Blue Clay – against staphylococci, streptococci, Enterobacteriaceae and non-fermenting Gram-negative bacilli. The clay and its aqueous leachate were evaluated against the bacteria in biofilm and planktonic states. Time-kill studies were used to assess planktonic activity. Biofilms on medical-grade Teflon discs were treated with a hydrated clay suspension or leachate. For the planktonic studies, clay and leachate exhibited bactericidal activity against all strains tested, with the exception of leachate against Staphylococcus aureus IDRL-6169 and USA300. All strains treated with clay suspension and leachate resulted in statistically significant biofilm population reductions compared with controls, except S. aureus IDRL-6169 and USA300 (P ≤ 0.05). OMT Blue Clay and its aqueous leachate exhibited bactericidal activity against a range of human pathogens in the planktonic and biofilm states.

Original languageEnglish (US)
Pages (from-to)692-696
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume52
Issue number5
DOIs
StatePublished - Nov 1 2018

Fingerprint

Wound Infection
Iron
Bacteria
Biofilms
Staphylococcus aureus
Suspensions
clay
Polytetrafluoroethylene
Enterobacteriaceae
Streptococcus
Staphylococcus
Bacillus
Population

Keywords

  • Antibacterial clay
  • Biofilm
  • Drug-resistant bacteria

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Antibacterial activity of reduced iron clay against pathogenic bacteria associated with wound infections. / Caflisch, Katherine M.; Schmidt-Malan, Suzannah M.; Mandrekar, Jayawant N.; Karau, Melissa J.; Nicklas, Jonathan P.; Williams, Lynda; Patel, Robin.

In: International Journal of Antimicrobial Agents, Vol. 52, No. 5, 01.11.2018, p. 692-696.

Research output: Contribution to journalArticle

Caflisch, Katherine M. ; Schmidt-Malan, Suzannah M. ; Mandrekar, Jayawant N. ; Karau, Melissa J. ; Nicklas, Jonathan P. ; Williams, Lynda ; Patel, Robin. / Antibacterial activity of reduced iron clay against pathogenic bacteria associated with wound infections. In: International Journal of Antimicrobial Agents. 2018 ; Vol. 52, No. 5. pp. 692-696.
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