TY - JOUR
T1 - Anti-immunology
T2 - Evasion of the host immune system by bacterial and viral pathogens
AU - Finlay, B. Brett
AU - McFadden, Grant
N1 - Funding Information:
Work in our laboratories is supported by grants from the Canadian Institutes of Health Research (CIHR), the National Cancer Institute of Canada, the Howard Hughes Medical Institute (HHMI), and Genome Canada. B.B.F. is a CIHR Distinguished Investigator, an HHMI International Research Scholar, and the University of British Columbia Peter Wall Distinguished Professor. GM holds a Canada Research Chair in Molecular Virology and is an HHMI International Research Scholar. We would like to thank Brian Coombes for graphical assistance with the figure and Doris Hall for technical assistance. We apologize to our colleagues whose papers we were unable to cite due to space limitations.
PY - 2006/2/24
Y1 - 2006/2/24
N2 - Multicellular organisms possess very sophisticated defense mechanisms that are designed to effectively counter the continual microbial insult of the environment within the vertebrate host. However, successful microbial pathogens have in turn evolved complex and efficient methods to overcome innate and adaptive immune mechanisms, which can result in disease or chronic infections. Although the various virulence strategies used by viral and bacterial pathogens are numerous, there are several general mechanisms that are used to subvert and exploit immune systems that are shared between these diverse microbial pathogens. The success of each pathogen is directly dependant on its ability to mount an effective anti-immune response within the infected host, which can ultimately result in acute disease, chronic infection, or pathogen clearance. In this review, we highlight and compare some of the many molecular mechanisms that bacterial and viral pathogens use to evade host immune defenses.
AB - Multicellular organisms possess very sophisticated defense mechanisms that are designed to effectively counter the continual microbial insult of the environment within the vertebrate host. However, successful microbial pathogens have in turn evolved complex and efficient methods to overcome innate and adaptive immune mechanisms, which can result in disease or chronic infections. Although the various virulence strategies used by viral and bacterial pathogens are numerous, there are several general mechanisms that are used to subvert and exploit immune systems that are shared between these diverse microbial pathogens. The success of each pathogen is directly dependant on its ability to mount an effective anti-immune response within the infected host, which can ultimately result in acute disease, chronic infection, or pathogen clearance. In this review, we highlight and compare some of the many molecular mechanisms that bacterial and viral pathogens use to evade host immune defenses.
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U2 - 10.1016/j.cell.2006.01.034
DO - 10.1016/j.cell.2006.01.034
M3 - Review article
C2 - 16497587
AN - SCOPUS:32944462309
SN - 0092-8674
VL - 124
SP - 767
EP - 782
JO - Cell
JF - Cell
IS - 4
ER -