Anti-craving effects of environmental enrichment

Kenneth J. Thiel, Federico Sanabria, Nathan S. Pentkowski, Janet Neisewander

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

We hypothesized that environmental enrichment in rats may reduce cocaine-seeking behaviour elicited by cocaine-priming injections and by cocaine-associated cues. Rats trained to self-administer cocaine while housed in isolated conditions were then assigned to live in isolation or an enriched environment for 21 d of forced abstinence. Subsequently, extinction and reinstatement of cocaine-seeking behaviour (operant responses without cocaine available) were assessed. Expt 1 showed that enrichment resulted in less cocaine-seeking behaviour during extinction and cue-elicited reinstatement compared to continued isolation housing, but had no effect on cocaine-primed reinstatement. A subsequent experiment, which included a pair-housed group to control for potential isolation stress, again demonstrated that enrichment attenuated cocaine seeking during extinction, but not cocaine-primed reinstatement, relative to both isolation and pair-housed conditions. The findings suggest that enrichment reduces the impact of cocaine-associated environmental stimuli, and hence it may be a useful intervention for attenuating cue-elicited craving in humans.

Original languageEnglish (US)
Pages (from-to)1151-1156
Number of pages6
JournalInternational Journal of Neuropsychopharmacology
Volume12
Issue number9
DOIs
StatePublished - Oct 2009

Fingerprint

Cocaine
Cues
Craving
Control Groups
Injections

Keywords

  • Cocaine
  • drug-seeking behaviour
  • environmental enrichment
  • reinstatement
  • self-administration

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Anti-craving effects of environmental enrichment. / Thiel, Kenneth J.; Sanabria, Federico; Pentkowski, Nathan S.; Neisewander, Janet.

In: International Journal of Neuropsychopharmacology, Vol. 12, No. 9, 10.2009, p. 1151-1156.

Research output: Contribution to journalArticle

@article{7acf147d067d4e13b830d7bd719caa20,
title = "Anti-craving effects of environmental enrichment",
abstract = "We hypothesized that environmental enrichment in rats may reduce cocaine-seeking behaviour elicited by cocaine-priming injections and by cocaine-associated cues. Rats trained to self-administer cocaine while housed in isolated conditions were then assigned to live in isolation or an enriched environment for 21 d of forced abstinence. Subsequently, extinction and reinstatement of cocaine-seeking behaviour (operant responses without cocaine available) were assessed. Expt 1 showed that enrichment resulted in less cocaine-seeking behaviour during extinction and cue-elicited reinstatement compared to continued isolation housing, but had no effect on cocaine-primed reinstatement. A subsequent experiment, which included a pair-housed group to control for potential isolation stress, again demonstrated that enrichment attenuated cocaine seeking during extinction, but not cocaine-primed reinstatement, relative to both isolation and pair-housed conditions. The findings suggest that enrichment reduces the impact of cocaine-associated environmental stimuli, and hence it may be a useful intervention for attenuating cue-elicited craving in humans.",
keywords = "Cocaine, drug-seeking behaviour, environmental enrichment, reinstatement, self-administration",
author = "Thiel, {Kenneth J.} and Federico Sanabria and Pentkowski, {Nathan S.} and Janet Neisewander",
year = "2009",
month = "10",
doi = "10.1017/S1461145709990472",
language = "English (US)",
volume = "12",
pages = "1151--1156",
journal = "The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)",
issn = "1461-1457",
publisher = "Cambridge University Press",
number = "9",

}

TY - JOUR

T1 - Anti-craving effects of environmental enrichment

AU - Thiel, Kenneth J.

AU - Sanabria, Federico

AU - Pentkowski, Nathan S.

AU - Neisewander, Janet

PY - 2009/10

Y1 - 2009/10

N2 - We hypothesized that environmental enrichment in rats may reduce cocaine-seeking behaviour elicited by cocaine-priming injections and by cocaine-associated cues. Rats trained to self-administer cocaine while housed in isolated conditions were then assigned to live in isolation or an enriched environment for 21 d of forced abstinence. Subsequently, extinction and reinstatement of cocaine-seeking behaviour (operant responses without cocaine available) were assessed. Expt 1 showed that enrichment resulted in less cocaine-seeking behaviour during extinction and cue-elicited reinstatement compared to continued isolation housing, but had no effect on cocaine-primed reinstatement. A subsequent experiment, which included a pair-housed group to control for potential isolation stress, again demonstrated that enrichment attenuated cocaine seeking during extinction, but not cocaine-primed reinstatement, relative to both isolation and pair-housed conditions. The findings suggest that enrichment reduces the impact of cocaine-associated environmental stimuli, and hence it may be a useful intervention for attenuating cue-elicited craving in humans.

AB - We hypothesized that environmental enrichment in rats may reduce cocaine-seeking behaviour elicited by cocaine-priming injections and by cocaine-associated cues. Rats trained to self-administer cocaine while housed in isolated conditions were then assigned to live in isolation or an enriched environment for 21 d of forced abstinence. Subsequently, extinction and reinstatement of cocaine-seeking behaviour (operant responses without cocaine available) were assessed. Expt 1 showed that enrichment resulted in less cocaine-seeking behaviour during extinction and cue-elicited reinstatement compared to continued isolation housing, but had no effect on cocaine-primed reinstatement. A subsequent experiment, which included a pair-housed group to control for potential isolation stress, again demonstrated that enrichment attenuated cocaine seeking during extinction, but not cocaine-primed reinstatement, relative to both isolation and pair-housed conditions. The findings suggest that enrichment reduces the impact of cocaine-associated environmental stimuli, and hence it may be a useful intervention for attenuating cue-elicited craving in humans.

KW - Cocaine

KW - drug-seeking behaviour

KW - environmental enrichment

KW - reinstatement

KW - self-administration

UR - http://www.scopus.com/inward/record.url?scp=78049248255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049248255&partnerID=8YFLogxK

U2 - 10.1017/S1461145709990472

DO - 10.1017/S1461145709990472

M3 - Article

VL - 12

SP - 1151

EP - 1156

JO - The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)

JF - The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)

SN - 1461-1457

IS - 9

ER -