Antagonism of RNase L is required for murine coronavirus replication in Kupffer cells and liver sinusoidal endothelial cells but not in hepatocytes

Agriculture & Biology

• Murine coronavirus 100%
• Kupffer cells 74%
• antagonism 55%
• endothelial cells 55%
• hepatocytes 47%
• hepatitis 33%
• Murine hepatitis virus 22%
• ligases 13%
• viruses 13%
• liver 11%
• gadolinium 10%
• ribosomal RNA 9%
• cells 8%
• cyclophosphamide 8%
• degradation 8%
• mice 7%
• virus replication 7%
• infection 7%
• macrophages 6%
• chlorides 5%
• kinetics 4%
• mutants 3%
• blood 3%
• assays 3%

Medicine & Life Sciences

• 2-5A-dependent ribonuclease 87%
• Murine hepatitis virus 77%
• Kupffer Cells 64%
• Hepatocytes 45%
• Endothelial Cells 39%
• Liver 27%
• Hepatitis 22%
• gadolinium chloride 9%
• 2',5'-Oligoadenylate Synthetase 9%
• 2',5'-oligoadenylate 8%
• Viruses 7%
• Host Microbial Interactions 7%
• Phosphoric Diester Hydrolases 6%
• Ligases 6%
• Myeloid Cells 6%
• Cyclophosphamide 5%
• Antiviral Agents 5%
• Virus Diseases 4%
• Kinetics 4%
• Macrophages 4%
• Growth 3%
• Infections 2%