Abstract
The progestin and AdipoQ receptor (PAQR) family of proteins comprises three distinct structural classes, each with seemingly different agonist specificities. For example, Class I receptors, like the human adiponectin receptors (AdipoR1 and AdipoR2), sense proteins with a particular three-dimensional fold, while Class II receptors are nonclassical membrane receptors for the steroid hormone progesterone. Using a previously developed heterologous expression system to study PAQR receptor activity, we demonstrate that human PAQRs from all three classes are antagonized by both 1(S),2(R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol, a ceramidase inhibitor, and TNFα, a homologue of adiponectin that functions antagonistically to both adiponectin and progesterone in human cells.
Original language | English (US) |
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Pages (from-to) | 5504-5506 |
Number of pages | 3 |
Journal | Biochemistry |
Volume | 48 |
Issue number | 24 |
DOIs | |
State | Published - Jun 23 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry