Animal models of age- and disease-related cognitive decline: Perspectives on the models and therapeutic strategies

Jeffrey H. Kordower, Don M. Gash

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The relative value of animals with memory impairments, due either to experimental lesions or aging processes, is dependent upon the specific hypothesis being tested. The experimental approaches described in the preceding reviews are valuable for basic studies on learning and memory in the mammalian brain. However, because of important differences between available model systems and human disease states, such as Alzheimer's disease, their use at present may be insufficient for understanding and developing treatment strategies for human cognitive dysfunctions. In this commentary, different aspects of animal models of memory dysfunction will be discussed relative to their ability to assess the structural and functional consequences of central nervous system (CNS) repair.

Original languageEnglish (US)
Pages (from-to)685-689
Number of pages5
JournalNeurobiology of Aging
Volume9
Issue numberC
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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