Aneuploidy in pancreatic insulinomas does not predict malignancy

F. Graeme-Cook, D. A. Bell, T. J. Flotte, F. Preffer, C. Pastel-Levy, G. Nardi, Carolyn Compton

Research output: Contribution to journalArticle

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Abstract

Nuclear deoxyribonucleic acid (DNA) ploidy studies with paraffin aembedded archival material from 14 pancreatic insulinomas were performed by flow cytometry. Clinical follow-up (2 to 17 years; mean, 8 years) was obtained for all patients. Half of the tumors had a normal DNA histogram and half exhibited an abnormal DNA profile consistent with DNA aneuploidy. Six of the seven patients with aneuploid tumors are alive and disease free (2 to 5 years postresection), and one is alive with metastatic disease. Of the seven patients with tumors showing normal DNA profiles, five are alive and disease free, one is dead of disease, and one is alive with metastatic disease. These data suggest that DNA ploidy analysis is unlikely to provide useful prognostic information for patients with insulinomas.

Original languageEnglish (US)
Pages (from-to)2365-2368
Number of pages4
JournalCancer
Volume66
Issue number11
DOIs
StatePublished - 1990
Externally publishedYes

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Insulinoma
Aneuploidy
DNA
Neoplasms
Ploidies
Paraffin
Flow Cytometry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Graeme-Cook, F., Bell, D. A., Flotte, T. J., Preffer, F., Pastel-Levy, C., Nardi, G., & Compton, C. (1990). Aneuploidy in pancreatic insulinomas does not predict malignancy. Cancer, 66(11), 2365-2368. https://doi.org/10.1002/1097-0142(19901201)66:11<2365::AID-CNCR2820661119>3.0.CO;2-L

Aneuploidy in pancreatic insulinomas does not predict malignancy. / Graeme-Cook, F.; Bell, D. A.; Flotte, T. J.; Preffer, F.; Pastel-Levy, C.; Nardi, G.; Compton, Carolyn.

In: Cancer, Vol. 66, No. 11, 1990, p. 2365-2368.

Research output: Contribution to journalArticle

Graeme-Cook, F, Bell, DA, Flotte, TJ, Preffer, F, Pastel-Levy, C, Nardi, G & Compton, C 1990, 'Aneuploidy in pancreatic insulinomas does not predict malignancy', Cancer, vol. 66, no. 11, pp. 2365-2368. https://doi.org/10.1002/1097-0142(19901201)66:11<2365::AID-CNCR2820661119>3.0.CO;2-L
Graeme-Cook F, Bell DA, Flotte TJ, Preffer F, Pastel-Levy C, Nardi G et al. Aneuploidy in pancreatic insulinomas does not predict malignancy. Cancer. 1990;66(11):2365-2368. https://doi.org/10.1002/1097-0142(19901201)66:11<2365::AID-CNCR2820661119>3.0.CO;2-L
Graeme-Cook, F. ; Bell, D. A. ; Flotte, T. J. ; Preffer, F. ; Pastel-Levy, C. ; Nardi, G. ; Compton, Carolyn. / Aneuploidy in pancreatic insulinomas does not predict malignancy. In: Cancer. 1990 ; Vol. 66, No. 11. pp. 2365-2368.
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