Androgen-deprivation therapy and metabolic syndrome in men with prostate cancer

Joanne M. Harrington, Dawn C. Schwenke, Dana Epstein, Donald E. Bailey

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Purpose/Objectives: To examine the trajectory of changes in body composition and metabolic profile in men who receive androgen-deprivation therapy (ADT) for prostate cancer. Design: Prospective longitudinal design with repeated measures. Setting: Urban medical center in the southwestern United States. Sample: 55 men starting radiation therapy for prostate cancer. Methods: Changes in the parameters of metabolic syndrome were estimated with ADT (n = 31) and non-ADT (n = 24) groups by repeated-measures analysis of variance implemented by general linear mixed-effects models. Models included interactions between groups and follow-up time to test differences between the groups. Main Research Variables: Body composition and metabolic variables. Findings: The ADT group demonstrated a transient increase in waist circumference at the nine-month time point and significant changes in measures of insulin resistance were noted at the three month point. Values for diastolic and systolic blood pressure, plasma glucose, high-density lipo-protein, and triglycerides were not altered for either group. Differences in metabolic variables or measures of body composition did not differ significantly between the groups. Conclusions: The findings demonstrate the development of insulin resistance in men receiving ADT as early as three months after starting ADT. Implications for Nursing: Addressing survivorship concerns can lead to the development of nursing interventions designed to reduce adverse effects associated with ADT.

    Original languageEnglish (US)
    Pages (from-to)21-29
    Number of pages9
    JournalOncology Nursing Forum
    Volume41
    Issue number1
    DOIs
    StatePublished - Jan 1 2014

    Fingerprint

    Androgens
    Prostatic Neoplasms
    Body Composition
    Insulin Resistance
    Nursing
    Therapeutics
    Southwestern United States
    Blood Pressure
    Metabolome
    Waist Circumference
    Group Psychotherapy
    Analysis of Variance
    Triglycerides
    Radiotherapy
    Survival Rate
    Glucose
    Research
    Proteins

    Keywords

    • Androgen-deprivation therapy
    • Metabolic syndrome
    • Prostate cancer

    ASJC Scopus subject areas

    • Oncology(nursing)

    Cite this

    Androgen-deprivation therapy and metabolic syndrome in men with prostate cancer. / Harrington, Joanne M.; Schwenke, Dawn C.; Epstein, Dana; Bailey, Donald E.

    In: Oncology Nursing Forum, Vol. 41, No. 1, 01.01.2014, p. 21-29.

    Research output: Contribution to journalArticle

    Harrington, Joanne M. ; Schwenke, Dawn C. ; Epstein, Dana ; Bailey, Donald E. / Androgen-deprivation therapy and metabolic syndrome in men with prostate cancer. In: Oncology Nursing Forum. 2014 ; Vol. 41, No. 1. pp. 21-29.
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