TY - JOUR
T1 - Ancestry-inclusive dog genomics challenges popular breed stereotypes
AU - Morrill, Kathleen
AU - Hekman, Jessica
AU - Li, Xue
AU - McClure, Jesse
AU - Logan, Brittney
AU - Goodman, Linda
AU - Gao, Mingshi
AU - Dong, Yinan
AU - Alonso, Marjie
AU - Carmichael, Elena
AU - Snyder-Mackler, Noah
AU - Alonso, Jacob
AU - Noh, Hyun Ji
AU - Johnson, Jeremy
AU - Koltookian, Michele
AU - Lieu, Charlie
AU - Megquier, Kate
AU - Swofford, Ross
AU - Turner-Maier, Jason
AU - White, Michelle E.
AU - Weng, Zhiping
AU - Colubri, Andrés
AU - Genereux, Diane P.
AU - Lord, Kathryn A.
AU - Karlsson, Elinor K.
N1 - Publisher Copyright:
Copyright © 2022 The Authors
PY - 2022/4/29
Y1 - 2022/4/29
N2 - Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed dogs and genotyping 2155 dogs. Most behavioral traits are heritable [heritability (h2) > 25%], and admixture patterns in mixed-breed dogs reveal breed propensities. Breed explains just 9% of behavioral variation in individuals. Genome-wide association analyses identify 11 loci that are significantly associated with behavior, and characteristic breed behaviors exhibit genetic complexity. Behavioral loci are not unusually differentiated in breeds, but breed propensities align, albeit weakly, with ancestral function. We propose that behaviors perceived as characteristic of modern breeds derive from thousands of years of polygenic adaptation that predates breed formation, with modern breeds distinguished primarily by aesthetic traits.
AB - Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed dogs and genotyping 2155 dogs. Most behavioral traits are heritable [heritability (h2) > 25%], and admixture patterns in mixed-breed dogs reveal breed propensities. Breed explains just 9% of behavioral variation in individuals. Genome-wide association analyses identify 11 loci that are significantly associated with behavior, and characteristic breed behaviors exhibit genetic complexity. Behavioral loci are not unusually differentiated in breeds, but breed propensities align, albeit weakly, with ancestral function. We propose that behaviors perceived as characteristic of modern breeds derive from thousands of years of polygenic adaptation that predates breed formation, with modern breeds distinguished primarily by aesthetic traits.
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U2 - 10.1126/science.abk0639
DO - 10.1126/science.abk0639
M3 - Article
C2 - 35482869
AN - SCOPUS:85129390220
SN - 0036-8075
VL - 376
JO - Science
JF - Science
IS - 6592
M1 - eabk0639
ER -