Issledovanie stabil'nosti promezhutochnykh polimerov fibrina, obrazuiushchikhsia v sisteme fibrinogen-trombin.

Translated title of the contribution: Analysis of the stability of the intermediate fibrin polymers formed in a fibrinogen-thrombin system

T. P. Ugarova, E. V. Lugovskoǐ, O. V. Gorkun, S. G. Derzskaia

Research output: Contribution to journalArticlepeer-review

Abstract

Intermediate fibrin polymers formed from fibrinogen at low thrombin concentrations under physiological conditions are studied for their stability. Smith's statement that intermediate fibrin oligomers are inert molecules whose further self-assembly is possible only under additional thrombin activation was not supported. It is shown that the intermediate fibrin polymer stability at pH 7.4 is not high because of a strong tendency to aggregation and the higher molecular weight of the polymer the less its stability. The polymer stability in solution increases with pH. Stability of soluble fibrin complexes in solution depends on their size, defined by environmental conditions and on the quantity of fibrinogen present.

Translated title of the contributionAnalysis of the stability of the intermediate fibrin polymers formed in a fibrinogen-thrombin system
Original languageUkranian
Pages (from-to)254-259
Number of pages6
JournalUkrainskii biokhimicheskii zhurnal
Volume55
Issue number3
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Analysis of the stability of the intermediate fibrin polymers formed in a fibrinogen-thrombin system'. Together they form a unique fingerprint.

Cite this