Issledovanie stabil'nosti promezhutochnykh polimerov fibrina, obrazuiushchikhsia v sisteme fibrinogen-trombin.

Translated title of the contribution: Analysis of the stability of the intermediate fibrin polymers formed in a fibrinogen-thrombin system

Tatiana Ugarova, E. V. Lugovskoǐ, O. V. Gorkun, S. G. Derzskaia

Research output: Contribution to journalArticle

Abstract

Intermediate fibrin polymers formed from fibrinogen at low thrombin concentrations under physiological conditions are studied for their stability. Smith's statement that intermediate fibrin oligomers are inert molecules whose further self-assembly is possible only under additional thrombin activation was not supported. It is shown that the intermediate fibrin polymer stability at pH 7.4 is not high because of a strong tendency to aggregation and the higher molecular weight of the polymer the less its stability. The polymer stability in solution increases with pH. Stability of soluble fibrin complexes in solution depends on their size, defined by environmental conditions and on the quantity of fibrinogen present.

Original languageUndefined/Unknown
Pages (from-to)254-259
Number of pages6
JournalUkrainskii biokhimicheskii zhurnal
Volume55
Issue number3
StatePublished - 1983
Externally publishedYes

Fingerprint

Fibrin
Thrombin
Fibrinogen
Polymers
Oligomers
Molecular Weight
Self assembly
Agglomeration
Chemical activation
Molecular weight
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Issledovanie stabil'nosti promezhutochnykh polimerov fibrina, obrazuiushchikhsia v sisteme fibrinogen-trombin. / Ugarova, Tatiana; Lugovskoǐ, E. V.; Gorkun, O. V.; Derzskaia, S. G.

In: Ukrainskii biokhimicheskii zhurnal, Vol. 55, No. 3, 1983, p. 254-259.

Research output: Contribution to journalArticle

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AU - Derzskaia, S. G.

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