Analysis of population genetic structure by DNA fingerprinting.

Research output: Contribution to journalReview article

161 Citations (Scopus)

Abstract

DNA fingerprint similarity is now being used widely to make inferences about the genetic structure of natural and domesticated populations, often with little regard to the limitations of such data. This paper provides an overview of the statistical theory of DNA fingerprint analysis with special focus on applications to natural populations for which little if anything is known about the detailed genetics of the DNA profiles. Approaches to estimating individual and population homozygosity, effective population size, population subdivision, and relatedness are reviewed, and issues concerning the biases and sampling properties of the statistics are discussed.

Original languageEnglish (US)
Pages (from-to)113-126
Number of pages14
JournalEXS
Volume58
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

DNA Fingerprinting
Genetic Structures
Population Genetics
Population
Selection Bias
Population Density
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Analysis of population genetic structure by DNA fingerprinting. / Lynch, Michael.

In: EXS, Vol. 58, 01.01.1991, p. 113-126.

Research output: Contribution to journalReview article

@article{cfb1f1da5bc74018bd9258ca0ab6eecf,
title = "Analysis of population genetic structure by DNA fingerprinting.",
abstract = "DNA fingerprint similarity is now being used widely to make inferences about the genetic structure of natural and domesticated populations, often with little regard to the limitations of such data. This paper provides an overview of the statistical theory of DNA fingerprint analysis with special focus on applications to natural populations for which little if anything is known about the detailed genetics of the DNA profiles. Approaches to estimating individual and population homozygosity, effective population size, population subdivision, and relatedness are reviewed, and issues concerning the biases and sampling properties of the statistics are discussed.",
author = "Michael Lynch",
year = "1991",
month = "1",
day = "1",
language = "English (US)",
volume = "58",
pages = "113--126",
journal = "Experientia. Supplementum",
issn = "1023-294X",
publisher = "Birkhauser Verlag Basel",

}

TY - JOUR

T1 - Analysis of population genetic structure by DNA fingerprinting.

AU - Lynch, Michael

PY - 1991/1/1

Y1 - 1991/1/1

N2 - DNA fingerprint similarity is now being used widely to make inferences about the genetic structure of natural and domesticated populations, often with little regard to the limitations of such data. This paper provides an overview of the statistical theory of DNA fingerprint analysis with special focus on applications to natural populations for which little if anything is known about the detailed genetics of the DNA profiles. Approaches to estimating individual and population homozygosity, effective population size, population subdivision, and relatedness are reviewed, and issues concerning the biases and sampling properties of the statistics are discussed.

AB - DNA fingerprint similarity is now being used widely to make inferences about the genetic structure of natural and domesticated populations, often with little regard to the limitations of such data. This paper provides an overview of the statistical theory of DNA fingerprint analysis with special focus on applications to natural populations for which little if anything is known about the detailed genetics of the DNA profiles. Approaches to estimating individual and population homozygosity, effective population size, population subdivision, and relatedness are reviewed, and issues concerning the biases and sampling properties of the statistics are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0025940964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025940964&partnerID=8YFLogxK

M3 - Review article

C2 - 1831155

AN - SCOPUS:0025940964

VL - 58

SP - 113

EP - 126

JO - Experientia. Supplementum

JF - Experientia. Supplementum

SN - 1023-294X

ER -