Abstract
DNA fingerprint similarity is now being used widely to make inferences about the genetic structure of natural and domesticated populations, often with little regard to the limitations of such data. This paper provides an overview of the statistical theory of DNA fingerprint analysis with special focus on applications to natural populations for which little if anything is known about the detailed genetics of the DNA profiles. Approaches to estimating individual and population homozygosity, effective population size, population subdivision, and relatedness are reviewed, and issues concerning the biases and sampling properties of the statistics are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-126 |
| Number of pages | 14 |
| Journal | EXS |
| Volume | 58 |
| State | Published - Jan 1 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Analysis of population genetic structure by DNA fingerprinting. / Lynch, Michael.
In: EXS, Vol. 58, 01.01.1991, p. 113-126.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Analysis of population genetic structure by DNA fingerprinting.
AU - Lynch, Michael
PY - 1991/1/1
Y1 - 1991/1/1
N2 - DNA fingerprint similarity is now being used widely to make inferences about the genetic structure of natural and domesticated populations, often with little regard to the limitations of such data. This paper provides an overview of the statistical theory of DNA fingerprint analysis with special focus on applications to natural populations for which little if anything is known about the detailed genetics of the DNA profiles. Approaches to estimating individual and population homozygosity, effective population size, population subdivision, and relatedness are reviewed, and issues concerning the biases and sampling properties of the statistics are discussed.
AB - DNA fingerprint similarity is now being used widely to make inferences about the genetic structure of natural and domesticated populations, often with little regard to the limitations of such data. This paper provides an overview of the statistical theory of DNA fingerprint analysis with special focus on applications to natural populations for which little if anything is known about the detailed genetics of the DNA profiles. Approaches to estimating individual and population homozygosity, effective population size, population subdivision, and relatedness are reviewed, and issues concerning the biases and sampling properties of the statistics are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025940964&partnerID=8YFLogxK
M3 - Review article
C2 - 1831155
AN - SCOPUS:0025940964
VL - 58
SP - 113
EP - 126
JO - Experientia. Supplementum
JF - Experientia. Supplementum
SN - 1023-294X
ER -