Analysis of negative and multiple HLA antigen disease associations

G. Thomson, F. W. Nicholas, W. F. Bodmer, M. E. O'Neill, P. W. Hedrick, E. Hudes

Research output: Contribution to journalArticle

Abstract

The nature and extent of negative and multiple HLA antigen disease associations are investigated theoretically under two models. The first model assumes that an HLA antigen is involved directly in predisposing individuals to disease. The second model assumes that the association of a particular HLA antigen(s) with a disease is the result of linkage disequilibrium between the allele determining the antigen and alleles at a nearby locus which confers susceptibility to disease. We determined whether observed decreases in antigen frequencies among a patient group are simply the inevitable result of the fact that if one or more alleles at a locus is increased in frequency, then others must be decreased. Under the antigen predisposing model exact predictions concerning allele and antigen class frequencies at the predisposing locus, and the non-predisposing loci, are given. The predictions are examined using HLA-DR data for multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)293-306
Number of pages14
JournalTissue Antigens
Volume26
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

HLA Antigens
Alleles
Antigens
Disease Susceptibility
Linkage Disequilibrium
HLA-DR Antigens
Multiple Sclerosis

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Thomson, G., Nicholas, F. W., Bodmer, W. F., O'Neill, M. E., Hedrick, P. W., & Hudes, E. (1985). Analysis of negative and multiple HLA antigen disease associations. Tissue Antigens, 26(5), 293-306.

Analysis of negative and multiple HLA antigen disease associations. / Thomson, G.; Nicholas, F. W.; Bodmer, W. F.; O'Neill, M. E.; Hedrick, P. W.; Hudes, E.

In: Tissue Antigens, Vol. 26, No. 5, 1985, p. 293-306.

Research output: Contribution to journalArticle

Thomson, G, Nicholas, FW, Bodmer, WF, O'Neill, ME, Hedrick, PW & Hudes, E 1985, 'Analysis of negative and multiple HLA antigen disease associations', Tissue Antigens, vol. 26, no. 5, pp. 293-306.
Thomson G, Nicholas FW, Bodmer WF, O'Neill ME, Hedrick PW, Hudes E. Analysis of negative and multiple HLA antigen disease associations. Tissue Antigens. 1985;26(5):293-306.
Thomson, G. ; Nicholas, F. W. ; Bodmer, W. F. ; O'Neill, M. E. ; Hedrick, P. W. ; Hudes, E. / Analysis of negative and multiple HLA antigen disease associations. In: Tissue Antigens. 1985 ; Vol. 26, No. 5. pp. 293-306.
@article{8d510c209b904159a76ddf59fbe7533c,
title = "Analysis of negative and multiple HLA antigen disease associations",
abstract = "The nature and extent of negative and multiple HLA antigen disease associations are investigated theoretically under two models. The first model assumes that an HLA antigen is involved directly in predisposing individuals to disease. The second model assumes that the association of a particular HLA antigen(s) with a disease is the result of linkage disequilibrium between the allele determining the antigen and alleles at a nearby locus which confers susceptibility to disease. We determined whether observed decreases in antigen frequencies among a patient group are simply the inevitable result of the fact that if one or more alleles at a locus is increased in frequency, then others must be decreased. Under the antigen predisposing model exact predictions concerning allele and antigen class frequencies at the predisposing locus, and the non-predisposing loci, are given. The predictions are examined using HLA-DR data for multiple sclerosis.",
author = "G. Thomson and Nicholas, {F. W.} and Bodmer, {W. F.} and O'Neill, {M. E.} and Hedrick, {P. W.} and E. Hudes",
year = "1985",
language = "English (US)",
volume = "26",
pages = "293--306",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Analysis of negative and multiple HLA antigen disease associations

AU - Thomson, G.

AU - Nicholas, F. W.

AU - Bodmer, W. F.

AU - O'Neill, M. E.

AU - Hedrick, P. W.

AU - Hudes, E.

PY - 1985

Y1 - 1985

N2 - The nature and extent of negative and multiple HLA antigen disease associations are investigated theoretically under two models. The first model assumes that an HLA antigen is involved directly in predisposing individuals to disease. The second model assumes that the association of a particular HLA antigen(s) with a disease is the result of linkage disequilibrium between the allele determining the antigen and alleles at a nearby locus which confers susceptibility to disease. We determined whether observed decreases in antigen frequencies among a patient group are simply the inevitable result of the fact that if one or more alleles at a locus is increased in frequency, then others must be decreased. Under the antigen predisposing model exact predictions concerning allele and antigen class frequencies at the predisposing locus, and the non-predisposing loci, are given. The predictions are examined using HLA-DR data for multiple sclerosis.

AB - The nature and extent of negative and multiple HLA antigen disease associations are investigated theoretically under two models. The first model assumes that an HLA antigen is involved directly in predisposing individuals to disease. The second model assumes that the association of a particular HLA antigen(s) with a disease is the result of linkage disequilibrium between the allele determining the antigen and alleles at a nearby locus which confers susceptibility to disease. We determined whether observed decreases in antigen frequencies among a patient group are simply the inevitable result of the fact that if one or more alleles at a locus is increased in frequency, then others must be decreased. Under the antigen predisposing model exact predictions concerning allele and antigen class frequencies at the predisposing locus, and the non-predisposing loci, are given. The predictions are examined using HLA-DR data for multiple sclerosis.

UR - http://www.scopus.com/inward/record.url?scp=0022405615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022405615&partnerID=8YFLogxK

M3 - Article

C2 - 3867175

AN - SCOPUS:0022405615

VL - 26

SP - 293

EP - 306

JO - HLA

JF - HLA

SN - 2059-2302

IS - 5

ER -