Analysis of field-effect biosensors using self-consistent 3d drift-diffusion and Monte-Carlo simulations

S. Baumgartner; M. Vasicek; A. Bulyha; N. Tassotti; C. Heitzinger

doi:10.1016/j.proeng.2011.12.101

Analysis of field-effect biosensors using self-consistent 3d drift-diffusion and Monte-Carlo simulations

S. Baumgartner, M. Vasicek, A. Bulyha, N. Tassotti, C. Heitzinger

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

Field-effect biosensors based on nanowires enjoy considerable popularity due to their high sensitivity and direct electrical readout [1]. However, crucial issues such as the influence of the biomolecules on the charge-carrier transport or the binding of molecules to the surface have not been described satisfactorily yet in a quantitative manner. In order to analyze these effects, we present simulation results based on a 3D macroscopic transport model coupled with Monte-Carlo simulations for the bio-functionalized surface layer. Excellent agreement with measurement data has been found, while detailed study of the influence of the most prominent biomolecules, namely double-stranded DNA and single-stranded DNA, on the current through the semiconductor transducer has been carried out.

Original language	English (US)
Title of host publication	Procedia Engineering
Pages	407-410
Number of pages	4
Volume	25
DOIs	https://doi.org/10.1016/j.proeng.2011.12.101
State	Published - 2011
Externally published	Yes
Event	25th Eurosensors Conference - Athens, Greece Duration: Sep 4 2011 → Sep 7 2011

Other

Other	25th Eurosensors Conference
Country/Territory	Greece
City	Athens
Period	9/4/11 → 9/7/11

Keywords

Field-effect biosensors
Field-effect DNA sensors
Sensor simulation
Silicon nanowire

ASJC Scopus subject areas

General Engineering

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10.1016/j.proeng.2011.12.101

Cite this

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title = "Analysis of field-effect biosensors using self-consistent 3d drift-diffusion and Monte-Carlo simulations",

abstract = "Field-effect biosensors based on nanowires enjoy considerable popularity due to their high sensitivity and direct electrical readout [1]. However, crucial issues such as the influence of the biomolecules on the charge-carrier transport or the binding of molecules to the surface have not been described satisfactorily yet in a quantitative manner. In order to analyze these effects, we present simulation results based on a 3D macroscopic transport model coupled with Monte-Carlo simulations for the bio-functionalized surface layer. Excellent agreement with measurement data has been found, while detailed study of the influence of the most prominent biomolecules, namely double-stranded DNA and single-stranded DNA, on the current through the semiconductor transducer has been carried out.",

keywords = "Field-effect biosensors, Field-effect DNA sensors, Sensor simulation, Silicon nanowire",

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year = "2011",

doi = "10.1016/j.proeng.2011.12.101",

language = "English (US)",

volume = "25",

pages = "407--410",

booktitle = "Procedia Engineering",

note = "25th Eurosensors Conference ; Conference date: 04-09-2011 Through 07-09-2011",

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T1 - Analysis of field-effect biosensors using self-consistent 3d drift-diffusion and Monte-Carlo simulations

AU - Baumgartner, S.

AU - Vasicek, M.

AU - Bulyha, A.

AU - Tassotti, N.

AU - Heitzinger, C.

PY - 2011

Y1 - 2011

N2 - Field-effect biosensors based on nanowires enjoy considerable popularity due to their high sensitivity and direct electrical readout [1]. However, crucial issues such as the influence of the biomolecules on the charge-carrier transport or the binding of molecules to the surface have not been described satisfactorily yet in a quantitative manner. In order to analyze these effects, we present simulation results based on a 3D macroscopic transport model coupled with Monte-Carlo simulations for the bio-functionalized surface layer. Excellent agreement with measurement data has been found, while detailed study of the influence of the most prominent biomolecules, namely double-stranded DNA and single-stranded DNA, on the current through the semiconductor transducer has been carried out.

AB - Field-effect biosensors based on nanowires enjoy considerable popularity due to their high sensitivity and direct electrical readout [1]. However, crucial issues such as the influence of the biomolecules on the charge-carrier transport or the binding of molecules to the surface have not been described satisfactorily yet in a quantitative manner. In order to analyze these effects, we present simulation results based on a 3D macroscopic transport model coupled with Monte-Carlo simulations for the bio-functionalized surface layer. Excellent agreement with measurement data has been found, while detailed study of the influence of the most prominent biomolecules, namely double-stranded DNA and single-stranded DNA, on the current through the semiconductor transducer has been carried out.

KW - Field-effect biosensors

KW - Field-effect DNA sensors

KW - Sensor simulation

KW - Silicon nanowire

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DO - 10.1016/j.proeng.2011.12.101

M3 - Conference contribution

AN - SCOPUS:84857146098

VL - 25

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EP - 410

BT - Procedia Engineering

T2 - 25th Eurosensors Conference

Y2 - 4 September 2011 through 7 September 2011

ER -

Analysis of field-effect biosensors using self-consistent 3d drift-diffusion and Monte-Carlo simulations

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Keywords

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