Abstract
(equation presented) Several conformationally rigid analogues of the methylvalerate subunit contained within the linker domain of the antitumor antibiotic bleomycin have been prepared. These compounds have been protected in a fashion suitable for the solid-phase synthesis of bleomycin. Bleomycin congeners containing these analogues should facilitate a more detailed understanding of the nature of the conformational bend that the methylvalerate moiety is thought to impart to the natural product.
Original language | English (US) |
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Pages (from-to) | 2867-2869 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 3 |
Issue number | 18 |
DOIs | |
State | Published - Sep 6 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry