TY - GEN
T1 - Analogies between structural and systems biology and systems-of-systems engineering in dynamic environments
AU - Moitra, Subhodeep
AU - Yanamala, Naveena
AU - Tastan, Oznur
AU - Singh, Irtisha
AU - Langmead, Christopher J.
AU - Klein-Seetharaman, Judith
PY - 2010
Y1 - 2010
N2 - Computer science and biology have inspired each other by drawing analogies. Biological molecules are even used directly as new material building blocks for creating next generation computer hard- and software. Recently, biology is moving to larger scales, generating datasets of high complexity and size. This allows moving from studies of individual biological entities such as proteins to their complex networks of interactions. Since cells are able to respond to perturbations over time, it is becoming an important variable in these studies. This is analogous to systems of systems engineering to operate in dynamic environments, requiring the efficient monitoring of external variables and intelligent choice of adequate responses. Here, we survey previous successes in exploiting analogies between biology and computer science and propose novel avenues and potential for cross-fertilization of research in dynamic systems modeling in biology and systems-of-systems engineering.
AB - Computer science and biology have inspired each other by drawing analogies. Biological molecules are even used directly as new material building blocks for creating next generation computer hard- and software. Recently, biology is moving to larger scales, generating datasets of high complexity and size. This allows moving from studies of individual biological entities such as proteins to their complex networks of interactions. Since cells are able to respond to perturbations over time, it is becoming an important variable in these studies. This is analogous to systems of systems engineering to operate in dynamic environments, requiring the efficient monitoring of external variables and intelligent choice of adequate responses. Here, we survey previous successes in exploiting analogies between biology and computer science and propose novel avenues and potential for cross-fertilization of research in dynamic systems modeling in biology and systems-of-systems engineering.
KW - Biological system modeling
KW - Communication system signaling
KW - Networks
KW - Proteins
UR - http://www.scopus.com/inward/record.url?scp=77956585026&partnerID=8YFLogxK
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U2 - 10.1109/SYSOSE.2010.5544104
DO - 10.1109/SYSOSE.2010.5544104
M3 - Conference contribution
AN - SCOPUS:77956585026
SN - 9781424481972
T3 - 2010 5th International Conference on System of Systems Engineering, SoSE 2010
BT - 2010 5th International Conference on System of Systems Engineering, SoSE 2010
T2 - 2010 5th International Conference on System of Systems Engineering, SoSE 2010
Y2 - 22 June 2010 through 24 June 2010
ER -