Anabolic hormone profiles in elite military men

Marcus K. Taylor; Shiloah A. Kviatkovsky; Lisa M. Hernández; Paul Sargent; Sabrina Segal; Douglas A. Granger

doi:10.1016/j.steroids.2016.04.001

Anabolic hormone profiles in elite military men

Marcus K. Taylor, Shiloah A. Kviatkovsky, Lisa M. Hernández, Paul Sargent, Sabrina Segal, Douglas A. Granger

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in this population. Overall, the men in this study displayed anabolic hormone profiles comparable to that of healthy, athletic populations. Consistent with the cortisol findings in our prior report, summary parameters of magnitude (hormone output) within the first hour after awakening displayed superior stability versus summary parameters of pattern for both DHEA (r range: 0.77-0.82) and testosterone (r range: 0.62-0.69). Summary parameters of evening function were stable for the two hormones (both p < 0.001), while the absolute decrease in testosterone across the day was a stable proxy of diurnal function (p < 0.001). Removal of noncompliant subjects did not appreciably affect concentration estimates for either hormone at any time point, nor did it alter the repeatability of any summary parameter. The first of its kind, this report enables accurate estimations of anabolic balance and resultant effects upon health and human performance in this highly resilient yet chronically stressed population.

Original language	English (US)
Pages (from-to)	41-48
Number of pages	8
Journal	Steroids
Volume	110
DOIs	https://doi.org/10.1016/j.steroids.2016.04.001
State	Published - Jun 1 2016
Externally published	Yes

Keywords

Anabolic
Dehydroepiandrosterone
Military
Special operations
Stress
Testosterone

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/j.steroids.2016.04.001

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title = "Anabolic hormone profiles in elite military men",

abstract = "We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in this population. Overall, the men in this study displayed anabolic hormone profiles comparable to that of healthy, athletic populations. Consistent with the cortisol findings in our prior report, summary parameters of magnitude (hormone output) within the first hour after awakening displayed superior stability versus summary parameters of pattern for both DHEA (r range: 0.77-0.82) and testosterone (r range: 0.62-0.69). Summary parameters of evening function were stable for the two hormones (both p < 0.001), while the absolute decrease in testosterone across the day was a stable proxy of diurnal function (p < 0.001). Removal of noncompliant subjects did not appreciably affect concentration estimates for either hormone at any time point, nor did it alter the repeatability of any summary parameter. The first of its kind, this report enables accurate estimations of anabolic balance and resultant effects upon health and human performance in this highly resilient yet chronically stressed population.",

keywords = "Anabolic, Dehydroepiandrosterone, Military, Special operations, Stress, Testosterone",

author = "Taylor, {Marcus K.} and Kviatkovsky, {Shiloah A.} and Hern{\'a}ndez, {Lisa M.} and Paul Sargent and Sabrina Segal and Granger, {Douglas A.}",

note = "Funding Information: Report number 15-50, supported by the Office of Naval Research (Code 30), under Work Unit No. N1204 . The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U.S. Government. Approved for public release; distribution is unlimited. U.S. Government Work (17 USC 105). Not copyrighted in the U.S. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.NHRC.2012.0006). Dr. Granger is founder and Chief Strategy and Senior Scientific Advisor at Salimetrics, LLC. His relationship with this entity is managed by the policies of the Conflict of Interest Committee at the Johns Hopkins University and the Office of Research Integrity and Assurance at Arizona State University. DAG and IISBR relocated from Arizona State University to UC Irvine in 2016, where similar policies will be established. Dr. Taylor is Scientific Advisor for Sports and Performance at Salimetrics, LLC (Carlsbad, CA). His relationship with this entity is consistent with, and managed by, the policies of the Department of Defense, Naval Medical Research Center Office of Ethics, and the Naval Health Research Center Commanding Officer and Institutional Review Board. The Authors would like to thank Michelle Lewark for editorial expertise.",

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doi = "10.1016/j.steroids.2016.04.001",

language = "English (US)",

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pages = "41--48",

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T1 - Anabolic hormone profiles in elite military men

AU - Taylor, Marcus K.

AU - Kviatkovsky, Shiloah A.

AU - Hernández, Lisa M.

AU - Sargent, Paul

AU - Segal, Sabrina

AU - Granger, Douglas A.

N1 - Funding Information: Report number 15-50, supported by the Office of Naval Research (Code 30), under Work Unit No. N1204 . The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U.S. Government. Approved for public release; distribution is unlimited. U.S. Government Work (17 USC 105). Not copyrighted in the U.S. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.NHRC.2012.0006). Dr. Granger is founder and Chief Strategy and Senior Scientific Advisor at Salimetrics, LLC. His relationship with this entity is managed by the policies of the Conflict of Interest Committee at the Johns Hopkins University and the Office of Research Integrity and Assurance at Arizona State University. DAG and IISBR relocated from Arizona State University to UC Irvine in 2016, where similar policies will be established. Dr. Taylor is Scientific Advisor for Sports and Performance at Salimetrics, LLC (Carlsbad, CA). His relationship with this entity is consistent with, and managed by, the policies of the Department of Defense, Naval Medical Research Center Office of Ethics, and the Naval Health Research Center Commanding Officer and Institutional Review Board. The Authors would like to thank Michelle Lewark for editorial expertise.

PY - 2016/6/1

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N2 - We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in this population. Overall, the men in this study displayed anabolic hormone profiles comparable to that of healthy, athletic populations. Consistent with the cortisol findings in our prior report, summary parameters of magnitude (hormone output) within the first hour after awakening displayed superior stability versus summary parameters of pattern for both DHEA (r range: 0.77-0.82) and testosterone (r range: 0.62-0.69). Summary parameters of evening function were stable for the two hormones (both p < 0.001), while the absolute decrease in testosterone across the day was a stable proxy of diurnal function (p < 0.001). Removal of noncompliant subjects did not appreciably affect concentration estimates for either hormone at any time point, nor did it alter the repeatability of any summary parameter. The first of its kind, this report enables accurate estimations of anabolic balance and resultant effects upon health and human performance in this highly resilient yet chronically stressed population.

AB - We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in this population. Overall, the men in this study displayed anabolic hormone profiles comparable to that of healthy, athletic populations. Consistent with the cortisol findings in our prior report, summary parameters of magnitude (hormone output) within the first hour after awakening displayed superior stability versus summary parameters of pattern for both DHEA (r range: 0.77-0.82) and testosterone (r range: 0.62-0.69). Summary parameters of evening function were stable for the two hormones (both p < 0.001), while the absolute decrease in testosterone across the day was a stable proxy of diurnal function (p < 0.001). Removal of noncompliant subjects did not appreciably affect concentration estimates for either hormone at any time point, nor did it alter the repeatability of any summary parameter. The first of its kind, this report enables accurate estimations of anabolic balance and resultant effects upon health and human performance in this highly resilient yet chronically stressed population.

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KW - Dehydroepiandrosterone

KW - Military

KW - Special operations

KW - Stress

KW - Testosterone

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ER -

Anabolic hormone profiles in elite military men

Abstract

Keywords

ASJC Scopus subject areas

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