An update on cancer risk and surveillance in primary sclerosing cholangitis

Jennifer L. Horsley-Silva, Eduardo A. Rodriguez, Diana L. Franco, Keith Lindor

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Malignancy represents substantial morbidity and mortality in patients with primary sclerosing cholangitis (PSC). This subset of patients has been proven to be at increased risk for developing cholangiocarcinoma, gallbladder carcinoma and colorectal cancer in those with overlapping inflammatory bowel disease. Herein, we review the prevalence of these malignancies and recommend screening tools and current knowledge to reduce the disease burden in this population. Cholangiocarcinoma is the most dominant malignancy affecting PSC patients, with a lifetime risk ranging from 5% to 20%. We advocate for serial US or MRI/MRCP and CA 19-9 to screen for cholangiocarcinoma. Gallbladder cancer has a lifetime risk around 2% in this population and we agree with annual imaging for lesions as recommended by national guidelines. Patients with PSC and concomitant IBD are at increased risk of colorectal carcinoma from time of diagnosis and therefore should likely undergo annual surveillance. The low rates of hepatocellular cancer and pancreatic cancer indicate surveillance for these malignancies is less advantageous.

Original languageEnglish (US)
Pages (from-to)1103-1109
Number of pages7
JournalLiver International
Issue number8
StatePublished - Aug 2017


  • cancer surveillance
  • cholangiocarcinoma
  • cirrhosis
  • colorectal cancer
  • gallbladder cancer
  • hepatocellular carcinoma
  • primary sclerosing cholangitis

ASJC Scopus subject areas

  • Hepatology


Dive into the research topics of 'An update on cancer risk and surveillance in primary sclerosing cholangitis'. Together they form a unique fingerprint.

Cite this