An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss

J. C. Murray, K. H. Buetow, R. E. Ferrell, P. D. Sieberg, M. Fukuda

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Using a cDNA for glycophorin A (MN), we screened 10 unrelated Caucasians using 22 restriction enzymes for RFLPs. A common StuI RFLP was identified and shown to be in marked linkage disequilibrium with both the MN and Ss blood-group antigens in a larger group of unrelated Caucasians. This provides a DNA marker for a locus that has been of major importance in genetic and population studies. The demonstrated disequilibrium will prove useful in localizing the gene for glycophorin B and in studies of genetic and physical distances on human chromosomes.

Original languageEnglish (US)
Pages (from-to)149-151
Number of pages3
JournalCytogenetics and cell genetics
Volume47
Issue number3
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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