An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss

J. C. Murray, Kenneth Buetow, R. E. Ferrell, P. D. Sieberg, M. Fukuda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Using a cDNA for glycophorin A (MN), we screened 10 unrelated Caucasians using 22 restriction enzymes for RFLPs. A common StuI RFLP was identified and shown to be in marked linkage disequilibrium with both the MN and Ss blood-group antigens in a larger group of unrelated Caucasians. This provides a DNA marker for a locus that has been of major importance in genetic and population studies. The demonstrated disequilibrium will prove useful in localizing the gene for glycophorin B and in studies of genetic and physical distances on human chromosomes.

Original languageEnglish (US)
Pages (from-to)149-151
Number of pages3
JournalCytogenetics and Cell Genetics
Volume47
Issue number3
StatePublished - 1988
Externally publishedYes

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Glycophorin
Linkage Disequilibrium
Restriction Fragment Length Polymorphisms
Population Genetics
Human Chromosomes
Blood Group Antigens
Genetic Markers
Complementary DNA
Enzymes
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Murray, J. C., Buetow, K., Ferrell, R. E., Sieberg, P. D., & Fukuda, M. (1988). An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss. Cytogenetics and Cell Genetics, 47(3), 149-151.

An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss. / Murray, J. C.; Buetow, Kenneth; Ferrell, R. E.; Sieberg, P. D.; Fukuda, M.

In: Cytogenetics and Cell Genetics, Vol. 47, No. 3, 1988, p. 149-151.

Research output: Contribution to journalArticle

Murray, JC, Buetow, K, Ferrell, RE, Sieberg, PD & Fukuda, M 1988, 'An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss', Cytogenetics and Cell Genetics, vol. 47, no. 3, pp. 149-151.
Murray, J. C. ; Buetow, Kenneth ; Ferrell, R. E. ; Sieberg, P. D. ; Fukuda, M. / An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss. In: Cytogenetics and Cell Genetics. 1988 ; Vol. 47, No. 3. pp. 149-151.
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