An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss

J. C. Murray; K. H. Buetow; R. E. Ferrell; P. D. Sieberg; M. Fukuda

doi:10.1159/000132534

An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss

J. C. Murray, K. H. Buetow, R. E. Ferrell, P. D. Sieberg, M. Fukuda

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Using a cDNA for glycophorin A (MN), we screened 10 unrelated Caucasians using 22 restriction enzymes for RFLPs. A common StuI RFLP was identified and shown to be in marked linkage disequilibrium with both the MN and Ss blood-group antigens in a larger group of unrelated Caucasians. This provides a DNA marker for a locus that has been of major importance in genetic and population studies. The demonstrated disequilibrium will prove useful in localizing the gene for glycophorin B and in studies of genetic and physical distances on human chromosomes.

Original language	English (US)
Pages (from-to)	149-151
Number of pages	3
Journal	Cytogenetics and cell genetics
Volume	47
Issue number	3
DOIs	https://doi.org/10.1159/000132534
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss",

abstract = "Using a cDNA for glycophorin A (MN), we screened 10 unrelated Caucasians using 22 restriction enzymes for RFLPs. A common StuI RFLP was identified and shown to be in marked linkage disequilibrium with both the MN and Ss blood-group antigens in a larger group of unrelated Caucasians. This provides a DNA marker for a locus that has been of major importance in genetic and population studies. The demonstrated disequilibrium will prove useful in localizing the gene for glycophorin B and in studies of genetic and physical distances on human chromosomes.",

author = "Murray, {J. C.} and Buetow, {K. H.} and Ferrell, {R. E.} and Sieberg, {P. D.} and M. Fukuda",

year = "1988",

doi = "10.1159/000132534",

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T1 - An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss

AU - Murray, J. C.

AU - Buetow, K. H.

AU - Ferrell, R. E.

AU - Sieberg, P. D.

AU - Fukuda, M.

PY - 1988

Y1 - 1988

N2 - Using a cDNA for glycophorin A (MN), we screened 10 unrelated Caucasians using 22 restriction enzymes for RFLPs. A common StuI RFLP was identified and shown to be in marked linkage disequilibrium with both the MN and Ss blood-group antigens in a larger group of unrelated Caucasians. This provides a DNA marker for a locus that has been of major importance in genetic and population studies. The demonstrated disequilibrium will prove useful in localizing the gene for glycophorin B and in studies of genetic and physical distances on human chromosomes.

AB - Using a cDNA for glycophorin A (MN), we screened 10 unrelated Caucasians using 22 restriction enzymes for RFLPs. A common StuI RFLP was identified and shown to be in marked linkage disequilibrium with both the MN and Ss blood-group antigens in a larger group of unrelated Caucasians. This provides a DNA marker for a locus that has been of major importance in genetic and population studies. The demonstrated disequilibrium will prove useful in localizing the gene for glycophorin B and in studies of genetic and physical distances on human chromosomes.

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An RFLP for glycophorin A (MN) is in linkage disequilibrium with MN and Ss

Abstract

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