TY - JOUR
T1 - An open science study of ageing in companion dogs
AU - The Dog Aging Project Consortium
AU - Creevy, Kate E.
AU - Akey, Joshua M.
AU - Kaeberlein, Matt
AU - Promislow, Daniel E.L.
AU - Barnett, Brian G.
AU - Benton, Brooke
AU - Borenstein, Elhanan
AU - Castelhano, Marta G.
AU - Chou, Lucy
AU - Collins, Devin
AU - Coleman, Amanda E.
AU - Crowder, Kyle
AU - Dunbar, Matthew D.
AU - Evans, Jeremy
AU - Fajt, Virginia R.
AU - Fitzpatrick, Annette L.
AU - Jeffery, Unity
AU - Jonlin, Erica C.
AU - Karlsson, Elinor K.
AU - Kerr, Kathleen F.
AU - Lee, Hannah
AU - Levine, Jonathan M.
AU - Ma, Jing
AU - McClelland, Robyn L.
AU - McNulty, Kellyn E.
AU - Morrill, Kathleen
AU - Nam, Yunbi
AU - Ruple, Audrey
AU - Schwartz, Stephen M.
AU - Shrager, Sandi
AU - Snyder-Mackler, Noah
AU - Thistlethwaite, William
AU - Tolbert, M. Katherine
AU - Urfer, Silvan R.
AU - Wilfond, Benjamin S.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022/2/3
Y1 - 2022/2/3
N2 - The Dog Aging Project is a long-term longitudinal study of ageing in tens of thousands of companion dogs. The domestic dog is among the most variable mammal species in terms of morphology, behaviour, risk of age-related disease and life expectancy. Given that dogs share the human environment and have a sophisticated healthcare system but are much shorter-lived than people, they offer a unique opportunity to identify the genetic, environmental and lifestyle factors associated with healthy lifespan. To take advantage of this opportunity, the Dog Aging Project will collect extensive survey data, environmental information, electronic veterinary medical records, genome-wide sequence information, clinicopathology and molecular phenotypes derived from blood cells, plasma and faecal samples. Here, we describe the specific goals and design of the Dog Aging Project and discuss the potential for this open-data, community science study to greatly enhance understanding of ageing in a genetically variable, socially relevant species living in a complex environment.
AB - The Dog Aging Project is a long-term longitudinal study of ageing in tens of thousands of companion dogs. The domestic dog is among the most variable mammal species in terms of morphology, behaviour, risk of age-related disease and life expectancy. Given that dogs share the human environment and have a sophisticated healthcare system but are much shorter-lived than people, they offer a unique opportunity to identify the genetic, environmental and lifestyle factors associated with healthy lifespan. To take advantage of this opportunity, the Dog Aging Project will collect extensive survey data, environmental information, electronic veterinary medical records, genome-wide sequence information, clinicopathology and molecular phenotypes derived from blood cells, plasma and faecal samples. Here, we describe the specific goals and design of the Dog Aging Project and discuss the potential for this open-data, community science study to greatly enhance understanding of ageing in a genetically variable, socially relevant species living in a complex environment.
UR - http://www.scopus.com/inward/record.url?scp=85123974421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123974421&partnerID=8YFLogxK
U2 - 10.1038/s41586-021-04282-9
DO - 10.1038/s41586-021-04282-9
M3 - Review article
C2 - 35110758
AN - SCOPUS:85123974421
SN - 0028-0836
VL - 602
SP - 51
EP - 57
JO - Nature
JF - Nature
IS - 7895
ER -