TY - JOUR
T1 - An on-chip system to monitor the pH of cell culture media
AU - Shah, Sahil
AU - Arafa, Hany
AU - Blain Christen, Jennifer
PY - 2014
Y1 - 2014
N2 - We presents an ion sensitive field effect transistor to measure the pH of the cell culture media of human mammary adenocarcinoma (SKBR3). We use a drift mitigation technique that cycles the transistor to reset the drift in the system. We use to technique in the system to demonstrate an integrated system to monitor the pH continuously. As a part of the system a pulse width modulation circuit is designed in a 0.5 μm CMOS process which cycles the vertical electric field of the ion sensitive field effect transistor to reset the threshold voltage drift. We demonstrate the viability of a complete integrated system implementing our drift mitigation technique to monitor cultured cells. The integration is important in this application to allow for autonomous operation inside an incubator during cell culture.
AB - We presents an ion sensitive field effect transistor to measure the pH of the cell culture media of human mammary adenocarcinoma (SKBR3). We use a drift mitigation technique that cycles the transistor to reset the drift in the system. We use to technique in the system to demonstrate an integrated system to monitor the pH continuously. As a part of the system a pulse width modulation circuit is designed in a 0.5 μm CMOS process which cycles the vertical electric field of the ion sensitive field effect transistor to reset the threshold voltage drift. We demonstrate the viability of a complete integrated system implementing our drift mitigation technique to monitor cultured cells. The integration is important in this application to allow for autonomous operation inside an incubator during cell culture.
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U2 - 10.1109/EMBC.2014.6944191
DO - 10.1109/EMBC.2014.6944191
M3 - Article
C2 - 25570559
SN - 1557-170X
VL - 2014
SP - 2745
EP - 2748
JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
ER -