An interrupted time series evaluation of a hepatitis C intervention for persons with HIV

Rae Jean Proeschold-Bell, Bettina Hoeppner, Baishakhi Taylor, Sarah Cohen, Rachel Blouin, Beth Stringfield, Andrew J. Muir

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Accurate HCV knowledge is lacking among high-risk groups, including people with HIV/AIDS (PLWHA). Liver disease primarily due to HCV has emerged as a serious cause of mortality among PLWHA. We used an Interrupted Time Series design to evaluate a social-ecologically based intervention for PLWHA, where an infectious disease clinic serving a six-county intervention area was monitored before (7 months) and after (17 months) intervention onset. The intervention included education of PLWHA and medical providers, HIV/HCV support groups, and adaptation of the patient chart top sheet to include HCV test information. Clinic-level outcomes were assessed prospectively every other week for 2 years by interviewing patients (n = 259) with clinic appointments on assessment days. Abrupt, gradual and delayed intervention effects were tested. Weighted regression analyses showed higher average HCV knowledge and a higher prevalence of patients reporting HCV discussion with their medical providers after intervention onset. A delayed effect was found for HCV awareness, and a gradually increasing effect was found for knowing one's HCV status. Other communities may consider adopting this intervention. Additional HCV interventions for PLWHA with HIV are needed.

Original languageEnglish (US)
Pages (from-to)1721-1731
Number of pages11
JournalAIDS and Behavior
Issue number8
StatePublished - Nov 2011
Externally publishedYes


  • HIV
  • Hepatitis C
  • Interrupted time series
  • Intervention research
  • Prevention

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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