An improved source of bryostatin 10, bugula neritina from the gulf of aomori, japan

Yoshiaki Kamano, Hui Ping Zhang, Akiya Hino, Motoyuki Yoshida, George Pettit, Cherry L. Herald, Hideji Itokawa

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Bryostatins have been isolated from diverse Japanese coastal specimens of Bugula neritina guided by inhibitory activity against fertilized sea urchin egg cell division. B. neritina from the Gulf of Aomori, Japan, has been found to contain bryostatin 10 [1b] in high yield (10 -3%) for this class of compounds. The 1H-and 13C-nmr signals of bryostatin 10 [1b] were reassigned by 2D nmr techniques. The conformation of bryostatin 10 [1b] in solution was revealed by nmr studies. This compound also exhibited activity in a steroidogenesis assay by increasing the production of adrenocortical hormones nearly twofold.

Original languageEnglish (US)
Pages (from-to)1868-1875
Number of pages8
JournalJournal of Natural Products
Volume58
Issue number12
DOIs
StatePublished - Dec 1995

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'An improved source of bryostatin 10, bugula neritina from the gulf of aomori, japan'. Together they form a unique fingerprint.

  • Cite this

    Kamano, Y., Zhang, H. P., Hino, A., Yoshida, M., Pettit, G., Herald, C. L., & Itokawa, H. (1995). An improved source of bryostatin 10, bugula neritina from the gulf of aomori, japan. Journal of Natural Products, 58(12), 1868-1875. https://doi.org/10.1021/np50126a009