### Abstract

Fitness is expected to decrease with inbreeding in proportion to the amount of deleterious genetic variation present in a population. The effect of inbreeding on survivorship is usually modeled as a negative exponential relationship, and this model has been widely used to estimate the amount of deleterious genetic variation in populations. Linear regression has traditionally been used to estimate the parameters ol the model, including the number of lethal equivalents. This article describes an alternative method for estimating parameters and their confidence limits: the maximum likelihood approach. The accuracy of regression and maximum likelihood estimates of the number of lethal equivalents is compared through simulation. The maximum likelihood approach is found to be both median unbiased and capable of estimating confidence limits with nearly the stated degree of accuracy, while the linear regression approach is found to be median biased. The significance of this on previous estimates of inbreeding depression is discussed.

Original language | English (US) |
---|---|

Pages (from-to) | 481-497 |

Number of pages | 17 |

Journal | Zoo Biology |

Volume | 17 |

Issue number | 6 |

State | Published - 1998 |

### Fingerprint

### Keywords

- Endangered species
- Fitness
- Lethal equivalents
- Maximum likelihood

### ASJC Scopus subject areas

- Animal Science and Zoology
- veterinary(all)

### Cite this

*Zoo Biology*,

*17*(6), 481-497.

**An improved method for estimating inbreeding depression in pedigrees.** / Kalinowski, Steven T.; Hedrick, Philip W.

Research output: Contribution to journal › Article

*Zoo Biology*, vol. 17, no. 6, pp. 481-497.

}

TY - JOUR

T1 - An improved method for estimating inbreeding depression in pedigrees

AU - Kalinowski, Steven T.

AU - Hedrick, Philip W.

PY - 1998

Y1 - 1998

N2 - Fitness is expected to decrease with inbreeding in proportion to the amount of deleterious genetic variation present in a population. The effect of inbreeding on survivorship is usually modeled as a negative exponential relationship, and this model has been widely used to estimate the amount of deleterious genetic variation in populations. Linear regression has traditionally been used to estimate the parameters ol the model, including the number of lethal equivalents. This article describes an alternative method for estimating parameters and their confidence limits: the maximum likelihood approach. The accuracy of regression and maximum likelihood estimates of the number of lethal equivalents is compared through simulation. The maximum likelihood approach is found to be both median unbiased and capable of estimating confidence limits with nearly the stated degree of accuracy, while the linear regression approach is found to be median biased. The significance of this on previous estimates of inbreeding depression is discussed.

AB - Fitness is expected to decrease with inbreeding in proportion to the amount of deleterious genetic variation present in a population. The effect of inbreeding on survivorship is usually modeled as a negative exponential relationship, and this model has been widely used to estimate the amount of deleterious genetic variation in populations. Linear regression has traditionally been used to estimate the parameters ol the model, including the number of lethal equivalents. This article describes an alternative method for estimating parameters and their confidence limits: the maximum likelihood approach. The accuracy of regression and maximum likelihood estimates of the number of lethal equivalents is compared through simulation. The maximum likelihood approach is found to be both median unbiased and capable of estimating confidence limits with nearly the stated degree of accuracy, while the linear regression approach is found to be median biased. The significance of this on previous estimates of inbreeding depression is discussed.

KW - Endangered species

KW - Fitness

KW - Lethal equivalents

KW - Maximum likelihood

UR - http://www.scopus.com/inward/record.url?scp=0032258501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032258501&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032258501

VL - 17

SP - 481

EP - 497

JO - Zoo Biology

JF - Zoo Biology

SN - 0733-3188

IS - 6

ER -