An improved method for estimating inbreeding depression in pedigrees

Steven T. Kalinowski, Philip W. Hedrick

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Fitness is expected to decrease with inbreeding in proportion to the amount of deleterious genetic variation present in a population. The effect of inbreeding on survivorship is usually modeled as a negative exponential relationship, and this model has been widely used to estimate the amount of deleterious genetic variation in populations. Linear regression has traditionally been used to estimate the parameters ol the model, including the number of lethal equivalents. This article describes an alternative method for estimating parameters and their confidence limits: the maximum likelihood approach. The accuracy of regression and maximum likelihood estimates of the number of lethal equivalents is compared through simulation. The maximum likelihood approach is found to be both median unbiased and capable of estimating confidence limits with nearly the stated degree of accuracy, while the linear regression approach is found to be median biased. The significance of this on previous estimates of inbreeding depression is discussed.

Original languageEnglish (US)
Pages (from-to)481-497
Number of pages17
JournalZoo Biology
Volume17
Issue number6
StatePublished - Dec 1 1998

Keywords

  • Endangered species
  • Fitness
  • Lethal equivalents
  • Maximum likelihood

ASJC Scopus subject areas

  • Animal Science and Zoology

Fingerprint Dive into the research topics of 'An improved method for estimating inbreeding depression in pedigrees'. Together they form a unique fingerprint.

  • Cite this

    Kalinowski, S. T., & Hedrick, P. W. (1998). An improved method for estimating inbreeding depression in pedigrees. Zoo Biology, 17(6), 481-497.