TY - GEN
T1 - An implantable hydrogel check valve for hydrocephalus treatment—development and in vitro measurements
AU - Schwerdt, H. N.
AU - Bristol, R. E.
AU - Chae, Junseok
N1 - Publisher Copyright:
© 2014TRF.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Permanently stable cerebrospinal fluid (CSF) draining devices are needed for treating hydrocephalus, a debilitating brain disorder. Currently implemented shunts are unreliable as long term implants primarily due to their largely protracted form. The proposed hydrogel valve attempts to generate greater permanency as a chronic implant by forming a direct CSF channel across the physiologically blocked natural valve formations, the arachnoid granulations (AG), and restoring near-natural CSF draining operations. In this way, all CSF draining operations are confined within the cranium. The valve relies on innate hydrogel swelling phenomenon to strengthen reverse flow sealing at idle and negative pressures. In vitro measurements in emulated CSF solutions display operation spanning targeted range of normal healthy draining (cracking pressure, PT ~ 1 – 110 mmH2O and outflow hydraulic resistance, Rh ~ 24 – 152 mmH2O/mL/min), with negligible reverse flow leakage. Overtime tests demonstrate the valve’s operational reproducibility and in situ feasibility, substantiating its potential for use as a permanent implant.
AB - Permanently stable cerebrospinal fluid (CSF) draining devices are needed for treating hydrocephalus, a debilitating brain disorder. Currently implemented shunts are unreliable as long term implants primarily due to their largely protracted form. The proposed hydrogel valve attempts to generate greater permanency as a chronic implant by forming a direct CSF channel across the physiologically blocked natural valve formations, the arachnoid granulations (AG), and restoring near-natural CSF draining operations. In this way, all CSF draining operations are confined within the cranium. The valve relies on innate hydrogel swelling phenomenon to strengthen reverse flow sealing at idle and negative pressures. In vitro measurements in emulated CSF solutions display operation spanning targeted range of normal healthy draining (cracking pressure, PT ~ 1 – 110 mmH2O and outflow hydraulic resistance, Rh ~ 24 – 152 mmH2O/mL/min), with negligible reverse flow leakage. Overtime tests demonstrate the valve’s operational reproducibility and in situ feasibility, substantiating its potential for use as a permanent implant.
UR - http://www.scopus.com/inward/record.url?scp=85061923533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061923533&partnerID=8YFLogxK
U2 - 10.31438/trf.hh2014.96
DO - 10.31438/trf.hh2014.96
M3 - Conference contribution
AN - SCOPUS:85061923533
T3 - Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop
SP - 355
EP - 358
BT - 2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014
A2 - Allen, Mark G.
A2 - Mehregany, Mehran
PB - Transducer Research Foundation
T2 - 2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014
Y2 - 8 June 2014 through 12 June 2014
ER -