An implantable hydrogel check valve for hydrocephalus treatment—development and in vitro measurements

H. N. Schwerdt, R. E. Bristol, Junseok Chae

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Permanently stable cerebrospinal fluid (CSF) draining devices are needed for treating hydrocephalus, a debilitating brain disorder. Currently implemented shunts are unreliable as long term implants primarily due to their largely protracted form. The proposed hydrogel valve attempts to generate greater permanency as a chronic implant by forming a direct CSF channel across the physiologically blocked natural valve formations, the arachnoid granulations (AG), and restoring near-natural CSF draining operations. In this way, all CSF draining operations are confined within the cranium. The valve relies on innate hydrogel swelling phenomenon to strengthen reverse flow sealing at idle and negative pressures. In vitro measurements in emulated CSF solutions display operation spanning targeted range of normal healthy draining (cracking pressure, PT ~ 1 – 110 mmH2O and outflow hydraulic resistance, Rh ~ 24 – 152 mmH2O/mL/min), with negligible reverse flow leakage. Overtime tests demonstrate the valve’s operational reproducibility and in situ feasibility, substantiating its potential for use as a permanent implant.

Original languageEnglish (US)
Title of host publication2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014
EditorsMark G. Allen, Mehran Mehregany
PublisherTransducer Research Foundation
Pages355-358
Number of pages4
ISBN (Electronic)9781940470016
DOIs
StatePublished - 2014
Event2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014 - Hilton Head Island, United States
Duration: Jun 8 2014Jun 12 2014

Publication series

NameTechnical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

Conference

Conference2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014
CountryUnited States
CityHilton Head Island
Period6/8/146/12/14

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Hardware and Architecture

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