An empirical comparison of short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) for relatedness estimation in Chinese rhesus macaques (Macaca mulatta)

Cody T. Ross, Jessica A. Weise, Sarah Bonnar, David Nolin, Jessica Satkoski Trask, David Glenn Smith, Betsy Ferguson, James Ha, H. Michael Kubisch, Amanda Vinson, Sreetharan Kanthaswamy

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We compare the effectiveness of short tandem repeat (STR) and single nucleotide polymorphism (SNP) genotypes for estimating pairwise relatedness, using molecular data and pedigree records from a captive Chinese rhesus macaque population at the California National Primate Research Center. We find that a panel of 81 SNPs is as effective at estimating first-order kin relationships as a panel of 14 highly polymorphic STRs. We note, however, that the selected STRs provide more precise predictions of relatedness than the selected SNPs, and may be preferred in contexts that require the discrimination of kin related more distantly than first-order relatives. Additionally, we compare the performance of three commonly used relatedness estimation algorithms, and find that the Wang [2002] algorithm outperforms other algorithms when analyzing STR data, while the Queller & Goodnight [1989] algorithm outperforms other algorithms when analyzing SNP data. Future research is needed to address the number of SNPs required to reach the discriminatory power of a standard STR panel in relatedness estimation for primate colony management.

Original languageEnglish (US)
Pages (from-to)313-324
Number of pages12
JournalAmerican Journal of Primatology
Volume76
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Macaca mulatta
relatedness
single nucleotide polymorphism
polymorphism
microsatellite repeats
primate
Primates
pedigree
genotype
comparison
prediction

Keywords

  • Colony management
  • Kinship
  • Macaca
  • Relatedness estimation
  • SNP
  • STR

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics

Cite this

An empirical comparison of short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) for relatedness estimation in Chinese rhesus macaques (Macaca mulatta). / Ross, Cody T.; Weise, Jessica A.; Bonnar, Sarah; Nolin, David; Satkoski Trask, Jessica; Smith, David Glenn; Ferguson, Betsy; Ha, James; Kubisch, H. Michael; Vinson, Amanda; Kanthaswamy, Sreetharan.

In: American Journal of Primatology, Vol. 76, No. 4, 2014, p. 313-324.

Research output: Contribution to journalArticle

Ross, Cody T. ; Weise, Jessica A. ; Bonnar, Sarah ; Nolin, David ; Satkoski Trask, Jessica ; Smith, David Glenn ; Ferguson, Betsy ; Ha, James ; Kubisch, H. Michael ; Vinson, Amanda ; Kanthaswamy, Sreetharan. / An empirical comparison of short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) for relatedness estimation in Chinese rhesus macaques (Macaca mulatta). In: American Journal of Primatology. 2014 ; Vol. 76, No. 4. pp. 313-324.
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