An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin

Kyle F. Biegasiewicz, Jeffrey D.St Denis, Vincent M. Carroll, Ronny Priefer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Synthesis of the soy isoflavone, daidzein, and its derivatives, isoformononetin and dimethyldaidzein, through utilization of a novel synthetic pathway is reported. This synthesis employs an enamine addition and O-methylation of 2,4-dihydroxyacetophenone, a subsequent ring closure and iodination, followed by a Suzuki coupling with PEG 10000. Demethylation of either isoformononetin or dimethyldaidzein afforded daidzein.

Original languageEnglish (US)
Pages (from-to)4408-4410
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number33
DOIs
StatePublished - Aug 18 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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