An efficient route to C-4 linked imidazole nucleosides: synthesis of 2-carbamoyl-4-(2′-deoxy-β-d-ribofuranosyl)imidazole

Donald E. Bergstrom, Peiming Zhang

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Abstract

The first synthesis of an imidazole C-nucleoside linked through C-4, 2-carbamoyl-4-(2′-deoxy-β-d-ribofuranosyl)imidazole was achieved by way of a nine-step sequence starting from 2-deoxy-3,5-di-O-p-toluoyl-d-erythro-pentofuranosyl chloride.

Original languageEnglish (US)
Pages (from-to)6485-6488
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number45
DOIs
StatePublished - Nov 4 1991

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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