An array of microactuated microelectrodes for monitoring single-neuronal activity in rodents

Jitendran Muthuswamy, Murat Okandan, Aaron Gilletti, Michael S. Baker, Tilak Jain

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Arrays of microelectrodes used for monitoring single- and multi-neuronal action potentials often fail to record from the same population of neurons over a period of time for several technical and biological reasons. We report here a novel Neural Probe chip with a 3-channel microactuated microelectrode array that will enable precise repositioning of the individual microelectrodes within the brain tissue after implantation. Thermal microactuators and associated microelectrodes in the Neural Probe chip are microfabricated using the Sandia's Ultraplanar Multi-level MEMS Technology (SUMMiTV) process, a 5-layer polysilicon micromachining technology of the Sandia National labs, Albuquerque, NM. The Neural Probe chip enables precise bi-directional positioning of the microelectrodes in the brain with a step resolution in the order of 8.8 μm. The thermal microactuators allow for a linear translation of the microelectrodes of up to 5 mm in either direction making it suitable for positioning microelectrodes in deep structures of a rodent brain. The overall translation in either direction was reduced to approximately 2 mm after insulation of the microelectrodes with epoxy for monitoring multi-unit activity. Single unit recordings were obtained from the somatosensory cortex of adult rats over a period of three days demonstrating the feasibility of this technology. Further optimization of the microelectrode insulation and chip packaging will be necessary before this technology can be validated in chronic experiments.

Original languageEnglish (US)
Pages (from-to)1470-1477
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume52
Issue number8
DOIs
StatePublished - Aug 2005

Fingerprint

Microelectrodes
Monitoring
Microactuators
Brain
Insulation
Rodentia
Micromachining
Polysilicon
Neurons
MEMS
Rats
Packaging
Tissue

Keywords

  • Action-potentials
  • BioMEMS
  • Brain-implants
  • Microactuators
  • Neuro-prosthesis

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

An array of microactuated microelectrodes for monitoring single-neuronal activity in rodents. / Muthuswamy, Jitendran; Okandan, Murat; Gilletti, Aaron; Baker, Michael S.; Jain, Tilak.

In: IEEE Transactions on Biomedical Engineering, Vol. 52, No. 8, 08.2005, p. 1470-1477.

Research output: Contribution to journalArticle

Muthuswamy, Jitendran ; Okandan, Murat ; Gilletti, Aaron ; Baker, Michael S. ; Jain, Tilak. / An array of microactuated microelectrodes for monitoring single-neuronal activity in rodents. In: IEEE Transactions on Biomedical Engineering. 2005 ; Vol. 52, No. 8. pp. 1470-1477.
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