An anatomy of normal and malignant gene expression

Kathy Boon, Elisson C. Osório, Susan F. Greenhut, Carl F. Schaefer, Jennifer Shoemaker, Kornelia Polyak, Patrice J. Morin, Kenneth H. Buetow, Robert L. Strausberg, Sandro J. De Souza, Gregory J. Riggins

Research output: Contribution to journalArticle

253 Scopus citations

Abstract

A gene's expression pattern provides clues to its role in normal physiology and disease. To provide quantitative expression levels on a genome-wide scale, the Cancer Genome Anatomy Project (CGAP) uses serial analysis of gene expression (SAGE). Over 5 million transcript tags from more than 100 human cell types have been assembled. To enhance the utility of this data, the CGAP SAGE project created SAGE Genie, a web site for the analysis and presentation of SAGE data (http://cgap.nci.nih.gov/SAGE). SAGE Genie provides an automatic link between gene names and SAGE transcript levels, accounting for alternative transcription and many potential errors. These informatics advances provide a rapid and intuitive view of transcript expression in the human body or brain, displayed on the SAGE Anatomic Viewer. We report here an easily accessible view of nearly any gene's expression in a wide variety of malignant and normal tissues.

Original languageEnglish (US)
Pages (from-to)11287-11292
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number17
DOIs
StatePublished - Aug 20 2002

ASJC Scopus subject areas

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    Boon, K., Osório, E. C., Greenhut, S. F., Schaefer, C. F., Shoemaker, J., Polyak, K., Morin, P. J., Buetow, K. H., Strausberg, R. L., De Souza, S. J., & Riggins, G. J. (2002). An anatomy of normal and malignant gene expression. Proceedings of the National Academy of Sciences of the United States of America, 99(17), 11287-11292. https://doi.org/10.1073/pnas.152324199