An analysis of a dendritic neuron model with an active membrane site

Steven M. Baer, Charles Tier

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We formulate and analyze a mathematical model that couples an idealized dendrite to an active boundary site to investigate the nonlinear interaction between these passive and active membrane patches. The active site is represented mathematically as a nonlinear boundary condition to a passive cable equation in the form of a space-clamped FitzHugh-Nagumo (FHN) equation. We perform a bifurcation analysis for both steady and periodic perturbation at the active site. We first investigate the uncoupled space-clamped FHN equation alone and find that for periodic perturbation a transition from phase locked (periodic) to phase pulling (quasiperiodic) solutions exist. For the model coupling a passive cable with a FHN active site at the boundary, we show for steady perturbation that the interval for repetitive firing is a subset of the interval for the space-clamped case and shrinks to zero for strong coupling. The firing rate at the active site decreases as the coupling strength increases. For periodic perturbation we show that the transition from phase locked to phase pulling solutions is also dependent on the coupling strength.

Original languageEnglish (US)
Pages (from-to)137-161
Number of pages25
JournalJournal Of Mathematical Biology
Volume23
Issue number2
DOIs
StatePublished - Feb 1 1986
Externally publishedYes

Keywords

  • Bifurcation theory
  • Cable theory
  • Dendrite
  • Resonance
  • Threshold

ASJC Scopus subject areas

  • Modeling and Simulation
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics

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