An Age-Related Resistance Of Chickens To Marek'S Disease

Some Preliminary Observations

R. L. Witter, J. M. Sharma, J. J. Solomon, L. R. Champion

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Chickens of 2 strains, 20 to 22 weeks of age and free of prior infection, were substantially more resistant than 1-day-old chicks to mortality and tumor induction caused by exposure to Marek’s disease virus. These older chickens were refractory to inculation with up to 104chick tumor-inducing doses of Marek's disease virus and, following contact infection, lesion frequencies were 8 to 30% of corresponding responses in chick controls. Resistance in contact exposed chickens was observed as early as the 8th week and, although variable, did not increase appreciably through the 20th week. Median latent periods to death were similar regardless of age at exposure. Older birds were fully susceptible to infection with Marek's disease virus and were only slightly resistant to development of microscopic lesions, thus suggesting that this resistance might be mediated through enhancement of lesion regression. Age-related resistance was confirmed to be unrelated to previously described tumor resistance caused by prior infection or genetic constitution.

Original languageEnglish (US)
Pages (from-to)43-54
Number of pages12
JournalAvian Pathology
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

Fingerprint

Marek Disease
Mardivirus
lesions (animal)
Chickens
chickens
neoplasms
Viruses
Infection
chicks
infection
latent period
biological resistance
Neoplasms
Constitution and Bylaws
death
Birds
birds
dosage
Mortality

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology and Microbiology(all)
  • Food Animals

Cite this

An Age-Related Resistance Of Chickens To Marek'S Disease : Some Preliminary Observations. / Witter, R. L.; Sharma, J. M.; Solomon, J. J.; Champion, L. R.

In: Avian Pathology, Vol. 2, No. 1, 01.01.1973, p. 43-54.

Research output: Contribution to journalArticle

Witter, R. L. ; Sharma, J. M. ; Solomon, J. J. ; Champion, L. R. / An Age-Related Resistance Of Chickens To Marek'S Disease : Some Preliminary Observations. In: Avian Pathology. 1973 ; Vol. 2, No. 1. pp. 43-54.
@article{144b313d1206426db72cfd7d3aa04f1f,
title = "An Age-Related Resistance Of Chickens To Marek'S Disease: Some Preliminary Observations",
abstract = "Chickens of 2 strains, 20 to 22 weeks of age and free of prior infection, were substantially more resistant than 1-day-old chicks to mortality and tumor induction caused by exposure to Marek’s disease virus. These older chickens were refractory to inculation with up to 104chick tumor-inducing doses of Marek's disease virus and, following contact infection, lesion frequencies were 8 to 30{\%} of corresponding responses in chick controls. Resistance in contact exposed chickens was observed as early as the 8th week and, although variable, did not increase appreciably through the 20th week. Median latent periods to death were similar regardless of age at exposure. Older birds were fully susceptible to infection with Marek's disease virus and were only slightly resistant to development of microscopic lesions, thus suggesting that this resistance might be mediated through enhancement of lesion regression. Age-related resistance was confirmed to be unrelated to previously described tumor resistance caused by prior infection or genetic constitution.",
author = "Witter, {R. L.} and Sharma, {J. M.} and Solomon, {J. J.} and Champion, {L. R.}",
year = "1973",
month = "1",
day = "1",
doi = "10.1080/03079457309353780",
language = "English (US)",
volume = "2",
pages = "43--54",
journal = "Avian Pathology",
issn = "0307-9457",
publisher = "Taylor and Francis Ltd.",
number = "1",

}

TY - JOUR

T1 - An Age-Related Resistance Of Chickens To Marek'S Disease

T2 - Some Preliminary Observations

AU - Witter, R. L.

AU - Sharma, J. M.

AU - Solomon, J. J.

AU - Champion, L. R.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - Chickens of 2 strains, 20 to 22 weeks of age and free of prior infection, were substantially more resistant than 1-day-old chicks to mortality and tumor induction caused by exposure to Marek’s disease virus. These older chickens were refractory to inculation with up to 104chick tumor-inducing doses of Marek's disease virus and, following contact infection, lesion frequencies were 8 to 30% of corresponding responses in chick controls. Resistance in contact exposed chickens was observed as early as the 8th week and, although variable, did not increase appreciably through the 20th week. Median latent periods to death were similar regardless of age at exposure. Older birds were fully susceptible to infection with Marek's disease virus and were only slightly resistant to development of microscopic lesions, thus suggesting that this resistance might be mediated through enhancement of lesion regression. Age-related resistance was confirmed to be unrelated to previously described tumor resistance caused by prior infection or genetic constitution.

AB - Chickens of 2 strains, 20 to 22 weeks of age and free of prior infection, were substantially more resistant than 1-day-old chicks to mortality and tumor induction caused by exposure to Marek’s disease virus. These older chickens were refractory to inculation with up to 104chick tumor-inducing doses of Marek's disease virus and, following contact infection, lesion frequencies were 8 to 30% of corresponding responses in chick controls. Resistance in contact exposed chickens was observed as early as the 8th week and, although variable, did not increase appreciably through the 20th week. Median latent periods to death were similar regardless of age at exposure. Older birds were fully susceptible to infection with Marek's disease virus and were only slightly resistant to development of microscopic lesions, thus suggesting that this resistance might be mediated through enhancement of lesion regression. Age-related resistance was confirmed to be unrelated to previously described tumor resistance caused by prior infection or genetic constitution.

UR - http://www.scopus.com/inward/record.url?scp=0002362744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002362744&partnerID=8YFLogxK

U2 - 10.1080/03079457309353780

DO - 10.1080/03079457309353780

M3 - Article

VL - 2

SP - 43

EP - 54

JO - Avian Pathology

JF - Avian Pathology

SN - 0307-9457

IS - 1

ER -